ArticleAnnals of botany2012
Combined in silico/in vivo analysis of mechanisms providing for root apical meristem self-organization and maintenance.
Article in Annals of botany, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Hormonal regulation of root growth under moderately elevated temperatures.Annals of botany · 2025Review
- Computational modeling of plant root development: the art and the science.The New phytologist · 2025Review
- Modeling Arabidopsis root growth and development.Plant physiology · 2025Review
- Multi-scale mechanisms driving root regeneration: From regeneration competence to tissue repatterning.The Plant journal : for cell and molecular biology · 2024Review
- Re-Evaluation of Vascular Histogenesis in the Root Tips of Selected Species in the Poaceae Using New Methods: Analysis of the Plerome, Vascular Initials, Pericycle and Late-Maturing Metaxylem Vessels.Plants (Basel, Switzerland) · 2024Article
- Complementary roles for auxin and auxin signalling revealed by reverse engineering lateral root stable prebranch site formation.Development (Cambridge, England) · 2022Article
- Modeling Auxin Signaling in Roots: Auxin Computations.Cold Spring Harbor perspectives in biology · 2022Review
- A Sight on Single-Cell Transcriptomics in Plants Through the Prism of Cell-Based Computational Modeling Approaches: Benefits and Challenges for Data Analysis.Frontiers in genetics · 2021Review
- Rocks in the auxin stream: Wound-induced auxin accumulation andProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cell Dynamics in WOX5-Overexpressing Root Tips: The Impact of Local Auxin Biosynthesis.Frontiers in plant science · 2020Article
- Prospects for Declarative Mathematical Modeling of Complex Biological Systems.Bulletin of mathematical biology · 2019Article
- Salicylic Acid Affects Root Meristem Patterning via Auxin Distribution in a Concentration-Dependent Manner.Plant physiology · 2019Article
- Root Tropisms: Investigations on Earth and in Space to Unravel Plant Growth Direction.Frontiers in plant science · 2019Review
- Advances in Understanding the Mechanism of Action of the Auxin Permease AUX1.International journal of molecular sciences · 2018Review
- A dynamic genetic-hormonal regulatory network model explains multiple cellular behaviors of the root apical meristem of Arabidopsis thaliana.PLoS computational biology · 2017Article
- Spatiotemporal modelling of hormonal crosstalk explains the level and patterning of hormones and gene expression in Arabidopsis thaliana wild-type and mutant roots.The New phytologist · 2015Article
- Bimodal regulation of ICR1 levels generates self-organizing auxin distribution.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Systems analysis of auxin transport in the Arabidopsis root apex.The Plant cell · 2014Article
- Experimental data and computational modeling link auxin gradient and development in the Arabidopsis root.Frontiers in plant science · 2014Review
- Cell patterns emerge from coupled chemical and physical fields with cell proliferation dynamics: the Arabidopsis thaliana root as a study system.PLoS computational biology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsThe root apical meristem (RAM) is the plant stem cell niche which provides for the formation and continuous development of the root. Auxin is the main regulator of RAM functioning, and auxin maxima coincide with the sites of RAM initiation and maintenance. Auxin gradients are formed due to local auxin biosynthesis and polar auxin transport. The PIN family of auxin transporters plays a critical role in polar auxin transport, and two mechanisms of auxin maximum formation in the RAM based on PIN-mediated auxin transport have been proposed to date: the reverse fountain and the reflected flow mechanisms.
methodsThe two mechanisms are combined here in in silico studies of auxin distribution in intact roots and roots cut into two pieces in the proximal meristem region. In parallel, corresponding experiments were performed in vivo using DR5::GFP Arabidopsis plants. KEY
resultsThe reverse fountain and the reflected flow mechanism naturally cooperate for RAM patterning and maintenance in intact root. Regeneration of the RAM in decapitated roots is provided by the reflected flow mechanism. In the excised root tips local auxin biosynthesis either alone or in cooperation with the reverse fountain enables RAM maintenance.
conclusionsThe efficiency of a dual-mechanism model in guiding biological experiments on RAM regeneration and maintenance is demonstrated. The model also allows estimation of the concentrations of auxin and PINs in root cells during development and under various treatments. The dual-mechanism model proposed here can be a powerful tool for the study of several different aspects of auxin function in root.
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