Evidence map›Paper›PMID 22510306›Full record

ReviewMolecular aspects of medicine2012

Consequences of oxidative stress in age-related macular degeneration.

Stuart G Jarrett, Michael E Boulton

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular aspects of medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 285 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
285citing papers in PubMed, 5 pooled it
27.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

285 citing papers in PubMed, 5 syntheses or guidelines pooled it, 520 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  17. Functional polymorphisms in pigmentation-related genesBiochemistry and biophysics reports · 2026
    Article
  18. Review
  19. Article
  20. Article

225 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Stuart G JarrettDepartment of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, KY, USA.
Michael E Boulton
University of Florida · USUniversity of Kentucky · US

Funding

Vision Research CoreP30EY021721 · NEI · UNIVERSITY OF FLORIDA · PI HAUSWIRTH, WILLIAM W · 2011 to 2015
$2.8M
Targeting gamma-secretase activation for anti-angiogenesisR01EY018358 · NEI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BOULTON, MICHAEL EDWIN · 2007 to 2012
$2.2M
Autophagy: A critical factor in RPE aging and AMDR01EY019688 · NEI · UNIVERSITY OF FLORIDA · PI BOULTON, MICHAEL EDWIN · 2009 to 2012
$1.4M
Circadian-dependent autophagy in retinal maintenance and diabetesR21EY021626 · NEI · UNIVERSITY OF FLORIDA · PI BOULTON, MICHAEL EDWIN · 2012 to 2013
$394k
NEI NIH HHS EY018358NEI NIH HHS EY019688NEI NIH HHS EY021626NEI NIH HHS P30 EY021721NEI NIH HHS R01 EY018358NEI NIH HHS R01 EY019688NEI NIH HHS R21 EY021626
6 · The paper itself

Abstract

The retina resides in an environment that is primed for the generation of reactive oxygen species (ROS) and resultant oxidative damage. The retina is one of the highest oxygen-consuming tissues in the human body. The highest oxygen levels are found in the choroid, but this falls dramatically across the outermost retina, creating a large gradient of oxygen towards the retina and inner segments of the photoreceptors which contain high levels of polyunsaturated fatty acids. This micro-environment together with abundant photosensitizers, visible light exposure and a high energy demand supports a highly oxidative milieu. However, oxidative damage is normally minimized by the presence of a range of antioxidant and efficient repair systems. Unfortunately, as we age oxidative damage increases, antioxidant capacity decreases and the efficiency of reparative systems become impaired. The result is retinal dysfunction and cell loss leading to visual impairment. It appears that these age-related oxidative changes are a hallmark of early age-related macular degeneration (AMD) which, in combination with hereditary susceptibility and other retinal modifiers, can progress to the pathology and visual morbidity associated with advanced AMD. This review reassesses the consequences of oxidative stress in AMD and strategies for preventing or reversing oxidative damage in retinal tissues.

Indexed as

Oxidative StressAnimalsAntioxidantsHumansMacular DegenerationReactive Nitrogen SpeciesReactive Oxygen SpeciesRetinaAntioxidantsReactive Nitrogen SpeciesReactive Oxygen Species

Identifiers

PMID22510306
PMCPMC3392472
OpenAlexW2030628584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.