SynthesisAmerican journal of epidemiology2012
A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents.
Synthesis in American journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- Pooled it
- Fine particle components and health--a systematic review and meta-analysis of epidemiological time series studies of daily mortality and hospital admissions.Journal of exposure science & environmental epidemiologyPooled it
- The Role of the Gut-Liver Axis in the Development of Liver Diseases Induced by Selected Environmental Pollutants: A Narrative Review.International journal of molecular sciences · 2026Review
- Residential Exposure to PMPaediatric and perinatal epidemiology · 2025Article
- Air Quality and Health Impacts of Onshore Oil and Gas Flaring and Venting Activities Estimated Using Refined Satellite-Based Emissions.GeoHealth · 2024Article
- Spatiotemporal trends in PMAtmospheric environment (Oxford, England : 1994) · 2024Article
- Environmental Health, Racial/Ethnic Health Disparity, and Climate Impacts of Inter-Regional Freight Transport in the United States.Environmental science & technology · 2023Article
- Short-term exposure to fine particulate matter constituents and mortality: case-crossover evidence from 32 counties in China.Science China. Life sciences · 2022Article
- Accumulation of trace element content in the lungs of Sao Paulo city residents and its correlation to lifetime exposure to air pollution.Scientific reports · 2022Article
- Do temporal trends of associations between short-term exposure to fine particulate matter (PMEnvironmental research · 2022Article
- Drivers of air pollution variability during second wave of COVID-19 in Delhi, India.Urban climate · 2022Article
- Spatio-temporal variation in fine particulate matter and effect on air quality during the COVID-19 in New Delhi, India.Urban climate · 2021Article
- Exploration of PM mass, source, and component-related factors that might explain heterogeneity in daily PMAtmospheric environment (Oxford, England : 1994) · 2021Article
- Atmospheric conditions and composition that influence PMAtmospheric chemistry and physics · 2021Article
- A Spatiotemporal Prediction Model for Black Carbon in the Denver Metropolitan Area, 2009-2020.Environmental science & technology · 2021Article
- Mitigating the air pollution effect? The remarkable decline in the pollution-mortality relationship in Hong Kong.Journal of environmental economics and management · 2020Article
- Global Effect Factors for Exposure to Fine Particulate Matter.Environmental science & technology · 2019Article
- Acute Effects of Air Pollution and Noise from Road Traffic in a Panel of Young Healthy Adults.International journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Health risk assessments of particulate matter less than 2.5 μm in diameter (PM(2.5)) often assume that all constituents of PM(2.5) are equally toxic. While investigators in previous epidemiologic studies have evaluated health risks from various PM(2.5) constituents, few have conducted the analyses needed to directly inform risk assessments. In this study, the authors performed a literature review and conducted a multisite time-series analysis of hospital admissions and exposure to PM(2.5) constituents (elemental carbon, organic carbon matter, sulfate, and nitrate) in a population of 12 million US Medicare enrollees for the period 2000-2008. The literature review illustrated a general lack of multiconstituent models or insight about probabilities of differential impacts per unit of concentration change. Consistent with previous results, the multisite time-series analysis found statistically significant associations between short-term changes in elemental carbon and cardiovascular hospital admissions. Posterior probabilities from multiconstituent models provided evidence that some individual constituents were more toxic than others, and posterior parameter estimates coupled with correlations among these estimates provided necessary information for risk assessment. Ratios of constituent toxicities, commonly used in risk assessment to describe differential toxicity, were extremely uncertain for all comparisons. These analyses emphasize the subtlety of the statistical techniques and epidemiologic studies necessary to inform risk assessments of particle constituents.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.