ArticleFEMS microbiology letters2012
Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus.
Article in FEMS microbiology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Agricultural SDHIs Induce Azole Resistance in Aspergillus fumigatus via Mitochondrial Sdh1 Suppression.Mycopathologia · 2025Article
- Article
- Genomic Data Mining Reveals Abundant Uncharacterized Transporters inJournal of fungi (Basel, Switzerland) · 2022Article
- The Anti-Fungal Activity of Nitropropenyl Benzodioxole (NPBD), a Redox-Thiol Oxidant and Tyrosine Phosphatase Inhibitor.Antibiotics (Basel, Switzerland) · 2022Article
- Identification of Novel Mutations Contributing to Azole Tolerance of Aspergillus fumigatus throughAntimicrobial agents and chemotherapy · 2021Article
- Genome-Wide Association Analysis for Triazole Resistance inPathogens (Basel, Switzerland) · 2021Article
- Linking calcium signaling and mitochondrial function in fungal drug resistance.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Trichophyton rubrum Azole Resistance Mediated by a New ABC Transporter, TruMDR3.Antimicrobial agents and chemotherapy · 2019Article
- Article
- Emerging threat of triazole-resistant Aspergillus fumigatus.The Journal of antimicrobial chemotherapy · 2019Review
- Determination of Azole Resistance and TRMycopathologia · 2018Article
- Aspergillus fumigatusAntimicrobial agents and chemotherapy · 2018Article
- Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2017Article
- Article
- Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi.PloS one · 2016Article
- Resistance to antifungals that target CYP51.Journal of chemical biology · 2014Review
- Passive surveillance for azole-resistant Aspergillus fumigatus, United States, 2011-2013.Emerging infectious diseases · 2014Article
- MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?Frontiers in physiology · 2014Review
- cyp51A-Based mechanisms of Aspergillus fumigatus azole drug resistance present in clinical samples from Germany.Antimicrobial agents and chemotherapy · 2013Article
- An invisible threat: mutation-mediated resistance to triazole drugs inCurrent fungal infection reports · 2012Article
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6 authors.
Funding
Abstract
Azoles are currently the mainstay of antifungal treatment both in agricultural and in clinical settings. Although the target site of azole action is well studied, the basis of azole resistance and the ultimate mode of action of the drug in fungi are poorly understood. To gain a deeper insight into these aspects of azole action, restriction-mediated plasmid integration (REMI) was used to create azole sensitive and resistant strains of the clinically important fungus Aspergillus fumigatus. Four azole sensitive insertions and four azole-resistant insertions were characterized. Three phenotypes could be re-created in wild-type AF210 by reintegration of rescued plasmid and a further four could be confirmed by complementation of the mutant phenotype with a copy of the wild-type gene predicted to be disrupted by the original insertional event. Six insertions were in genes not previously associated with azole sensitivity or resistance. Two insertions occur in transporter genes that may affect drug efflux, whereas others may affect transcriptional regulation of sterol biosynthesis genes and NADH metabolism in the mitochondrion. Two insertions are in genes of unknown function.
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