ArticleACS nano2012
Optically stable biocompatible flame-made SiO2-coated Y2O3:Tb3+ nanophosphors for cell imaging.
Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Systemic antitumor immune response of doped yttria nanoscintillators under low-dose x-ray irradiation.Science advances · 2025Article
- Synergistic Effect of SiONanomaterials (Basel, Switzerland) · 2024Article
- An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver.Scientific reports · 2023Article
- Control of Particle Size in Flame Spray Pyrolysis of Tb-doped YMaterials (Basel, Switzerland) · 2020Article
- Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions.Chemical communications (Cambridge, England) · 2020Article
- High Surface Reactivity and Biocompatibility of YMolecules (Basel, Switzerland) · 2020Article
- Near-infrared excited luminescence andNanoscale advances · 2019Article
- Controlling the Two-Photon-Induced Photon Cascade Emission in a Gd(3+)/Tb(3+)-Codoped Glass for Multicolor Display.Scientific reports · 2016Article
- Toward Contactless Biology: Acoustophoretic DNA Transfection.Scientific reports · 2016Article
- The Yin: An adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity.Environmental science. Nano · 2014Article
- Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles.Particle and fibre toxicology · 2014Article
- Tracking translocation of industrially relevant engineered nanomaterials (ENMs) across alveolar epithelial monolayers in vitro.Nanotoxicology · 2014Article
- Engineering safer-by-design, transparent, silica-coated ZnO nanorods with reduced DNA damage potential.Environmental science. Nano · 2014Article
- A Safer Formulation Concept for Flame-Generated Engineered Nanomaterials.ACS sustainable chemistry & engineering · 2013Article
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Authors and funding
4 authors.
Funding
Abstract
Nanophosphors are light-emitting materials with stable optical properties that represent promising tools for bioimaging. The synthesis of nanophosphors, and thus the control of their surface properties, is, however, challenging. Here, flame aerosol technology is exploited to generate Tb-activated Y(2)O(3) nanophosphors (∼25 nm) encapsulated in situ by a nanothin amorphous inert SiO(2) film. The nanocrystalline core exhibits a bright green luminescence following the Tb(3+) ion transitions, while the hermetic SiO(2)-coating prevents any unspecific interference with cellular activities. The SiO(2)-coated nanophosphors display minimal photobleaching upon imaging and can be easily functionalized through surface absorption of biological molecules. Therefore, they can be used as bionanoprobes for cell detection and for long-term monitoring of cellular activities. As an example, we report on the interaction between epidermal growth factor (EGF)-functionalized nanophosphors and mouse melanoma cells. The cellular uptake of the nanophosphors is visualized with confocal microscopy, and the specific activation of EGF receptors is revealed with biochemical techniques. Altogether, our results establish SiO(2)-coated Tb-activated Y(2)O(3) nanophosphors as superior imaging tools for biological applications.
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