ArticleDevelopmental biology2012
Cis-regulatory logic driving glial cells missing: self-sustaining circuitry in later embryogenesis.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
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- Wound repair in sea urchin larvae involves pigment cells and blastocoelar cells.Developmental biology · 2022Article
- Conditional specification of endomesoderm.Cells & development · 2021Review
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- Gastrulation in the sea urchin.Current topics in developmental biology · 2020Review
- How Does the Regulatory Genome Work?Journal of computational biology : a journal of computational molecular cell biology · 2019Article
- Conserved regulatory state expression controlled by divergent developmental gene regulatory networks in echinoids.Development (Cambridge, England) · 2018Article
- Bacterial artificial chromosomes as recombinant reporter constructs to investigate gene expression and regulation in echinoderms.Briefings in functional genomics · 2018Review
- Notch-mediated lateral inhibition is an evolutionarily conserved mechanism patterning the ectoderm in echinoids.Development genes and evolution · 2018Article
- Regulatory states in the developmental control of gene expression.Briefings in functional genomics · 2017Review
- Assessing regulatory information in developmental gene regulatory networks.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- An Organismal Model for Gene Regulatory Networks in the Gut-Associated Immune Response.Frontiers in immunology · 2017Review
- Albinism as a visual, in vivo guide for CRISPR/Cas9 functionality in the sea urchin embryo.Molecular reproduction and development · 2016Article
- Perturbation of gut bacteria induces a coordinated cellular immune response in the purple sea urchin larva.Immunology and cell biology · 2016Article
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- Eric Davidson: Steps to a gene regulatory network for development.Developmental biology · 2016Article
- Robustness and Accuracy in Sea Urchin Developmental Gene Regulatory Networks.Frontiers in genetics · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The glial cells missing (gcm) regulatory gene of the sea urchin Strongylocentrotus purpuratus is first expressed in veg2 daughter cells as the genomic target of late cleavage stage Delta-Notch signaling from the skeletogenic mesoderm precursors. Gcm is required in veg2 progeny during late cleavages for the early phase of pigment cell precursor specification. Here we report on a later acting cis-regulatory module that assumes control of gcm expression by the early mesenchyme blastula stage and maintains it through pigment cell differentiation and dispersal. Cis-perturbation analyses reveal that the two critical elements within this late module are consensus matches to Gcm and Six1 binding sites. Significantly, six1 mRNA localizes to gcm+cells from the mesenchyme blastula stage onwards. Trans-perturbations with anti-sense morpholinos reveal a co-dependency between six1 and gcm. Six1 mRNA levels fall sharply after Gcm is depleted, while depleting Six1 leads to significant reductions in output of endogenous gcm or modular-reporters. These results support the conclusion gcm and six1 comprise a positive intergenic feedback loop in the mesodermal GRN. This often employed cross regulatory GRN feature here ensures self-sustaining gcm output in a cohort of fully specified pigment cell precursors at a relatively early developmental stage.
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