ArticlePloS one2012
Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Causal association between allergic diseases and short stature: a mendelian randomization study revealing the potential mediating role of inflammatory proteins.Jornal de pediatria · 2026Article
- Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota.Engineering (Beijing, China) · 2024Article
- Axin1's mystique in manipulating microbiome amidst colitis.Gut microbes · 2023Article
- Roles of host SUMOylation in bacterial pathogenesis.Infection and immunity · 2023Review
- Axin1: A novel scaffold protein joins the antiviral network of interferon.Molecular microbiology · 2022Article
- The chromosome-scale genome of the raccoon dog: Insights into its evolutionary characteristics.iScience · 2022Article
- Plasma biomarkers for systemic inflammation in COVID-19 survivors.Proteomics. Clinical applications · 2022Article
- Paneth Cell Alertness to Pathogens Maintained by Vitamin D Receptors.Gastroenterology · 2021Article
- The WNT Framework in Shaping Immune Cell Responses During Bacterial Infections.Frontiers in immunology · 2019Review
- Wnt Signaling: Pathogen Incursion and Immune Defense.Frontiers in immunology · 2019Review
- Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome.Nature genetics · 2018Article
- Novel Regulatory Roles of Wnt1 in Infection-Associated Colorectal Cancer.Neoplasia (New York, N.Y.) · 2018Article
- Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs.Tissue barriers · 2018Article
- Vitamin D receptor is a novel transcriptional regulator for Axin1.The Journal of steroid biochemistry and molecular biology · 2017Article
- Administration of defined microbiota is protective in a murine Salmonella infection model.Scientific reports · 2015Article
- STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.The Journal of clinical investigation · 2015Article
- Salmonella Engages Host MicroRNAs To Modulate SUMOylation: a New Arsenal for Intracellular Survival.Molecular and cellular biology · 2015Article
- Salmonella-infected crypt-derived intestinal organoid culture system for host-bacterial interactions.Physiological reports · 2014Article
- The Wnt/β-catenin signaling pathway controls the inflammatory response in infections caused by pathogenic bacteria.Mediators of inflammation · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAxin1 and its homolog Axin2 are scaffold proteins essential for regulating Wnt signaling. Axin-dependent regulation of Wnt is important for various developmental processes and human diseases. However, the involvement of Axin1 and Axin2 in host defense and inflammation remains to be determined. METHODS/PRINCIPAL
findingsHere, we report that Axin1, but not Axin2, plays an essential role in host-pathogen interaction mediated by the Wnt pathway. Pathogenic Salmonella colonization greatly reduces the level of Axin1 in intestinal epithelial cells. This reduction is regulated at the posttranslational level in early onset of the bacterial infection. Further analysis reveals that the DIX domain and Ser614 of Axin1 are necessary for the Salmonella-mediated modulation through ubiquitination and SUMOylation. CONCLUSION/SIGNIFICANCE: Axin1 apparently has a preventive effect on bacterial invasiveness and inflammatory response during the early stages of infection. The results suggest a distinct biological function of Axin1 and Axin2 in infectious disease and intestinal inflammation while they are functionally equivalent in developmental settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.