ArticleFrontiers in neurology2012
Glucoregulatory consequences and cardiorespiratory parameters in rats exposed to chronic-intermittent hypoxia: effects of the duration of exposure and losartan.
Article in Frontiers in neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Chronic intermittent hypoxia attenuates noradrenergic innervation of hypoglossal motor nucleus.Respiratory physiology & neurobiology · 2024Article
- Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex.Antioxidants (Basel, Switzerland) · 2021Article
- Telmisartan attenuates kidney apoptosis and autophagy-related protein expression levels in an intermittent hypoxia mouse model.Sleep & breathing = Schlaf & Atmung · 2019Article
- Blockade of Endothelin-1 Receptor Type B Ameliorates Glucose Intolerance and Insulin Resistance in a Mouse Model of Obstructive Sleep Apnea.Frontiers in endocrinology · 2018Article
- Plasma Exosomes and Improvements in Endothelial Function by Angiotensin 2 Type 1 Receptor or Cyclooxygenase 2 Blockade following Intermittent Hypoxia.Frontiers in neurology · 2017Article
- Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms.Comprehensive Physiology · 2016Review
- Inhibition of Lipolysis Ameliorates Diabetic Phenotype in a Mouse Model of Obstructive Sleep Apnea.American journal of respiratory cell and molecular biology · 2016Article
- Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease.Biological research · 2016Review
- Association between Glucose Metabolism and Sleep-disordered Breathing during REM Sleep.American journal of respiratory and critical care medicine · 2015Article
- Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea.Journal of thoracic disease · 2015Review
- The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms.Diabetology & metabolic syndrome · 2015Article
- The effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia.Respiratory physiology & neurobiology · 2014Article
- Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Carotid body, insulin, and metabolic diseases: unraveling the links.Frontiers in physiology · 2014Review
- The efficacy of antihypertensive drugs in chronic intermittent hypoxia conditions.Frontiers in physiology · 2014Review
- Intermittent hypoxia exacerbates pancreatic β-cell dysfunction in a mouse model of diabetes mellitus.Sleep · 2013Article
- Article
- Reduced c-Fos expression in medullary catecholaminergic neurons in rats 20 h after exposure to chronic intermittent hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObstructive sleep apnea (OSA) is associated with glucose intolerance. Both chronic sleep disruption and recurrent blood oxygen desaturations (chronic-intermittent hypoxia, CIH) may cause, or exacerbate, metabolic derangements.
methodsTo assess the impact of CIH alone, without accompanying upper airway obstructions, on the counter-regulatory response to glucose load and cardiorespiratory parameters, we exposed adult male Sprague-Dawley rats to CIH or sham room air exchanges for 10 h/day for 7, 21, or 35 days and then, 1 day after conclusion of CIH exposure, conducted intravenous glucose-tolerance tests (ivgtt) under urethane anesthesia. Additional rats underwent 35 days of CIH followed by 35 days of regular housing, or had 35 day-long CIH exposure combined with daily administration of the type 1 angiotensin II receptor antagonist, losartan (15 mg/kg, p.o.), and then were also subjected to ivgtt.
resultsCompared with the corresponding control groups, CIH rats had progressively reduced glucose-stimulated insulin release and impaired glucose clearance, only mildly elevated heart rate and/or arterial blood pressure and slightly reduced respiratory rate. The differences in insulin release between the CIH and sham-treated rats disappeared in the rats normally housed for 35 days after 35 days of CIH/sham exposure. The losartan-treated rats had improved insulin sensitivity, with no evidence of suppressed insulin release in the CIH group.
conclusionIn adult rats, the glucose-stimulated insulin release is gradually suppressed with the duration of exposure to CIH, but the effect is reversible. Elimination of the detrimental effect of CIH on insulin release by losartan suggests that CIH disrupts glucoregulation through angiotensin/catecholaminergic pathways. Accordingly, treatment with continuous positive airway pressure may ameliorate pre-diabetic conditions in OSA patients, in part, by reducing sympathoexcitatory effects of recurrent nocturnal hypoxia.
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