Evidence map›Paper›PMID 22509166›Full record

ArticleFrontiers in physiology2012

Molecular pathways of notch signaling in vascular smooth muscle cells.

Joshua Boucher, Thomas Gridley, Lucy Liaw

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. NOTCH3 and Pulmonary Arterial Hypertension.International journal of molecular sciences · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Polycystic kidneys: interaction of notch and renin.Clinical science (London, England : 1979) · 2023
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joshua BoucherCenter for Molecular Medicine, Maine Medical Center Research Institute Scarborough, ME, USA.
Thomas Gridley
Lucy Liaw
Maine Medical Center Research Institute · USUniversity of Maine · US

Funding

Contribution of Notch Signaling to Vascular RemodelingR01HL070865 · NHLBI · MAINE MEDICAL CENTER · PI LIAW, LUCY · 2003 to 2017
$4.6M
GENETIC CONTROL OF MESODERM AND NEURAL CREST FORMATIONR01HD034883 · NICHD · MAINEHEALTH · PI GRIDLEY, THOMAS HOOKER · 1998 to 2012
$4.4M
NHLBI NIH HHS R01 HL070865NICHD NIH HHS R01 HD034883
6 · The paper itself

Abstract

Notch signaling in the cardiovascular system is important during embryonic development, vascular repair of injury, and vascular pathology in humans. The vascular smooth muscle cell (VSMC) expresses multiple Notch receptors throughout its life cycle, and responds to Notch ligands as a regulatory mechanism of differentiation, recruitment to growing vessels, and maturation. The goal of this review is to provide an overview of the current understanding of the molecular basis for Notch regulation of VSMC phenotype. Further, we will explore Notch interaction with other signaling pathways important in VSMC.

Indexed as

Notchsignalingvascular smooth muscle

Identifiers

PMID22509166
PMCPMC3321637
OpenAlexW2112629089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.