ArticleFrontiers in systems neuroscience2012
Neuroimaging and neuromodulation: complementary approaches for identifying the neuronal correlates of tinnitus.
Article in Frontiers in systems neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Transcranial direct current stimulation in tinnitus patients: a systemic review and meta-analysis.TheScientificWorldJournal · 2012Pooled it
- The added value of auditory cortex transcranial random noise stimulation (tRNS) after bifrontal transcranial direct current stimulation (tDCS) for tinnitus.Journal of neural transmission (Vienna, Austria : 1996) · 2017Trial
- Triple-site rTMS for the treatment of chronic tinnitus: a randomized controlled trial.Scientific reports · 2016Trial
- The differential effect of low- versus high-frequency random noise stimulation in the treatment of tinnitus.Experimental brain research · 2015Trial
- Trial
- Changes in motor cortex excitability associated with temporal repetitive transcranial magnetic stimulation in tinnitus: hints for cross-modal plasticity?BMC neuroscience · 2014Trial
- Reversing pathologically increased EEG power by acoustic coordinated reset neuromodulation.Human brain mapping · 2014Trial
- Functional near-infrared spectroscopy to probe state- and trait-like conditions in chronic tinnitus: a proof-of-principle study.Neural plasticity · 2014Trial
- Trial
- Shared and Individual Resting-State MEG Network Signatures of Tinnitus Revealed by Holistic Graph Learning.IEEE open journal of engineering in medicine and biology · 2026Article
- Effect of Topical Intra-Auricular Lidocaine on Tinnitus: A Randomized Double-Blind Placebo-Controlled Study.International archives of otorhinolaryngology · 2025Article
- Tinnitus in patients with orofacial complaints.Head & face medicine · 2025Article
- Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients.Frontiers in neurology · 2025Review
- Auditory illusory models as proxies to investigate bottom-up and top-down neural networks of phantom perception.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Pain and the autonomic nervous system. The role of non-invasive neuromodulation with NESA microcurrents.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Effect of Cognitive Rehabilitation by Auditory Stroop Training on Quality of Life of Individuals with Tinnitus.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Targeting the Limbic System: Insights into Its Involvement in Tinnitus.International journal of molecular sciences · 2023Review
- Combined Bifrontal Transcranial Direct Current Stimulation and Auditory Stroop Training in Chronic Tinnitus.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Functional Magnetic Resonance Imaging and Obesity-Novel Ways to Seen the Unseen.Journal of clinical medicine · 2022Review
- Vulnerability to chronic stress and the phenotypic heterogeneity of presbycusis with subjective tinnitus.Frontiers in neuroscience · 2022Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An inherent limitation of functional imaging studies is their correlational approach. More information about critical contributions of specific brain regions can be gained by focal transient perturbation of neural activity in specific regions with non-invasive focal brain stimulation methods. Functional imaging studies have revealed that tinnitus is related to alterations in neuronal activity of central auditory pathways. Modulation of neuronal activity in auditory cortical areas by repetitive transcranial magnetic stimulation (rTMS) can reduce tinnitus loudness and, if applied repeatedly, exerts therapeutic effects, confirming the relevance of auditory cortex activation for tinnitus generation and persistence. Measurements of oscillatory brain activity before and after rTMS demonstrate that the same stimulation protocol has different effects on brain activity in different patients, presumably related to interindividual differences in baseline activity in the clinically heterogeneous study cohort. In addition to alterations in auditory pathways, imaging techniques also indicate the involvement of non-auditory brain areas, such as the fronto-parietal "awareness" network and the non-tinnitus-specific distress network consisting of the anterior cingulate cortex, anterior insula, and amygdale. Involvement of the hippocampus and the parahippocampal region putatively reflects the relevance of memory mechanisms in the persistence of the phantom percept and the associated distress. Preliminary studies targeting the dorsolateral prefrontal cortex, the dorsal anterior cingulate cortex, and the parietal cortex with rTMS and with transcranial direct current stimulation confirm the relevance of the mentioned non-auditory networks. Available data indicate the important value added by brain stimulation as a complementary approach to neuroimaging for identifying the neuronal correlates of the various clinical aspects of tinnitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.