ArticlePLoS genetics2012
Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression and function of an aquaporin.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
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- Maternal GABAergic and GnRH/corazonin pathway modulates egg diapause phenotype of the silkwormProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Reactive Oxygen Species Mediate Activity-Regulated Dendritic Plasticity Through NADPH Oxidase and Aquaporin Regulation.Frontiers in cellular neuroscience · 2021Article
- Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation inProceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Systemic corazonin signalling modulates stress responses and metabolism in Drosophila.Open biology · 2016Article
- Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster.Molecular biology and evolution · 2015Article
- Postmating reproductive barriers contribute to the incipient sexual isolation of the United States and Caribbean Drosophila melanogaster.Ecology and evolution · 2015Article
- Causes of natural variation in fitness: evidence from studies of Drosophila populations.Proceedings of the National Academy of Sciences of the United States of America · 2015Review
- A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-history adaptation.Evolution; international journal of organic evolution · 2014Article
- Genomic evidence of rapid and stable adaptive oscillations over seasonal time scales in Drosophila.PLoS genetics · 2014Article
- Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cross population.Genetics · 2014Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
To gain insight into the molecular genetic basis of standing variation in fitness related traits, we identify a novel factor that regulates the molecular and physiological basis of natural variation in female Drosophila melanogaster fecundity. Genetic variation in female fecundity in flies derived from a wild orchard population is heritable and largely independent of other measured life history traits. We map a portion of this variation to a single QTL and then use deficiency mapping to further refine this QTL to 5 candidate genes. Ubiquitous expression of RNAi against only one of these genes, an aquaporin encoded by Drip, reduces fecundity. Within our mapping population Drip mRNA level in the head, but not other tissues, is positively correlated with fecundity. We localize Drip expression to a small population of corazonin producing neurons located in the dorsolateral posterior compartments of the protocerebrum. Expression of Drip-RNAi using both the pan-neuronal ELAV-Gal4 and the Crz-Gal4 drivers reduces fecundity. Low-fecundity RILs have decreased Crz expression and increased expression of pale, the enzyme encoding the rate-limiting step in the production of dopamine, a modulator of insect life histories. Taken together these data suggest that natural variation in Drip expression in the corazonin producing neurons contributes to standing variation in fitness by altering the concentration of two neurohormones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.