ArticleMolecular vision2012
Association of insulin-like growth factor-1 polymorphisms with high myopia in the Chinese population.
Article in Molecular vision, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The G allele of the IGF1 rs2162679 SNP is a potential protective factor for any myopia: Updated systematic review and meta-analysis.PloS one · 2022Pooled it
- Association between Insulin-Like Growth Factor 1 Gene rs12423791 or rs6214 Polymorphisms and High Myopia: A Meta-Analysis.PloS one · 2015Pooled it
- Effects of IGF1 rs6214 Polymorphism and Milk Consumption on Serum Levels of IGF-1 and GH and Body Composition.Metabolites · 2025Article
- Myopia development: multifactorial interplay, molecular mechanisms and possible strategies.Frontiers in medicine · 2025Review
- Lipid Metabolism Regulators Are the Possible Determinant for Characteristics of Myopic Human Scleral Stroma Fibroblasts (HSSFs).International journal of molecular sciences · 2023Article
- Effect of insulin levels and plasma fasting glucose on refractive status in the United States population aged 12-19 years.Frontiers in medicine · 2023Article
- The Role of GJD2(Cx36) in Refractive Error Development.Investigative ophthalmology & visual science · 2022Review
- Association ofMolecular vision · 2022Article
- Probability of myopia in children with high refined carbohydrates consumption in France.BMC ophthalmology · 2020Article
- Association ofPeerJ · 2020Article
- HOXA9 is a novel myopia risk gene.BMC ophthalmology · 2019Article
- Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration.Investigative ophthalmology & visual science · 2019Article
- Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders.International journal of ophthalmology · 2018Review
- Insight into the molecular genetics of myopia.Molecular vision · 2017Review
- Genetic association study between INSULIN pathway related genes and high myopia in a Han Chinese population.Molecular biology reports · 2015Article
- The association between IGF-1 polymorphisms and high myopia.International journal of clinical and experimental medicine · 2015Article
- Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population.Clinical ophthalmology (Auckland, N.Z.) · 2013Article
- Insulin-like growth factor 1 is not associated with high myopia in a large Japanese cohort.Molecular vision · 2013Article
- Association study of fibroblast growth factor 10 (FGF10) polymorphisms with susceptibility to extreme myopia in a Japanese population.Molecular vision · 2013Article
- Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to determine whether genetic variants in the insulin-like growth factor-1 (IGF-1) gene were associated with high myopia in the Chinese population.
methodsA case-control association study of 421 unrelated Chinese patients with high myopia and 401 control subjects matched in ethnicity and gender was undertaken. Genomic DNA was prepared from peripheral blood. All individuals were genotyped for 7 tag single nucleotide polymorphisms (tSNPs) across the IGF-1 gene region. Genotypic distribution was tested for Hardy-Weinberg equilibrium. The genotype and allele frequencies were evaluated using the χ(2) tests. Bonferroni corrections for multiple comparisons were performed.
resultsThe polymorphism of rs12423791 showed positive association with extreme myopia (p(allel)=0.006 and p(allel1 recessive model)=0.004, respectively) after Bonferroni correction for multiple testing and the haplotype GC of rs5742629-rs12423791 was also associated with extreme myopia (p=0.033) after 50,000 permutations for multiple comparisons.
conclusionsThe polymorphism of rs12423791 in IGF-1 may be associated with extreme myopia in the Chinese population and should be investigated further.
Indexed as
Identifiers
22509095PMC3324364W2126663347What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.