Evidence map›Paper›PMID 22509076›Full record

ReviewWorld journal of gastroenterology2012

Hepatic echinococcosis: clinical and therapeutic aspects.

Giuseppe Nunnari, Marilia R Pinzone, Salvatore Gruttadauria, Benedetto M Celesia, Giordano Madeddu, Giulia Malaguarnera, Piero Pavone, Alessandro Cappellani, Bruno Cacopardo

Open access · bronzeAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 2 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 2 syntheses or guidelines pooled it, 369 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. PercutaneousWorld journal of gastroenterology · 2026
    Article
  12. Article
  13. Allergic symptoms in hydatid cyst; common or rare?Northern clinics of Istanbul · 2026
    Article
  14. Frequency and Genetic Characterization ofJournal of parasitology research · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Disseminated Peritoneal Hydatidosis: A Case Report.JNMA; journal of the Nepal Medical Association · 2025
    Article
  20. Article

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giuseppe NunnariDepartment of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, Via Palermo 636,95125ARNAS Garibaldi Nesima, Catania,Italy. gnunnari@hotmail.com
Marilia R Pinzone
Salvatore Gruttadauria
Benedetto M Celesia
Giordano Madeddu
Giulia Malaguarnera
Piero Pavone
Alessandro Cappellani
Bruno Cacopardo
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Echinococcosis or hydatid disease (HD) is a zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus. Hepatic echinococcosis is a life-threatening disease, mainly differentiated into alveolar and cystic forms, associated with Echinoccus multilocularis (E. multilocularis) and Echinococcus granulosus (E. granulosus) infection, respectively. Cystic echinococcosis (CE) has a worldwide distribution, while hepatic alveolar echinococcosis (AE) is endemic in the Northern hemisphere, including North America and several Asian and European countries, like France, Germany and Austria. E. granulosus young cysts are spherical, unilocular vesicles, consisting of an internal germinal layer and an outer acellular layer. Cyst expansion is associated with a host immune reaction and the subsequent development of a fibrous layer, called the pericyst; old cysts typically present internal septations and daughter cysts. E. multilocularis has a tumor-like, infiltrative behavior, which is responsible for tissue destruction and finally for liver failure. The liver is the main site of HD involvement, for both alveolar and cystic hydatidosis. HD is usually asymptomatic for a long period of time, because cyst growth is commonly slow; the most frequent symptoms are fatigue and abdominal pain. Patients may also present jaundice, hepatomegaly or anaphylaxis, due to cyst leakage or rupture. HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis; furthermore, the improvement of surgical techniques, the introduction of minimally invasive treatments [such as puncture, aspiration, injection, re-aspiration (PAIR)] and more effective drugs (such as benzoimidazoles) have deeply changed life expectancy and quality of life of patients with HD. The aim of this article is to provide an up-to-date review of biological, diagnostic, clinical and therapeutic aspects of hepatic echinococcosis.

Indexed as

ZoonosesAnimalsDiagnosis, DifferentialEchinococcosis, HepaticEchinococcusHost-Parasite InteractionsHumansAlbendazoleAlveolar echinococcosisCystic echinococcosisDiagnosisHydatidosisLiverPAIRTreatment

Identifiers

PMID22509076
PMCPMC3319940
OpenAlexW2028094465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.