ArticleProceedings of the National Academy of Sciences of the United States of America2012
Promiscuous restriction is a cellular defense strategy that confers fitness advantage to bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Iron and peroxide regulation of the PrrF sRNAs and a conserved ferritin family protein inJournal of bacteriology · 2026Article
- Identification and characterization of a new HNH restriction endonuclease with unusual properties.Applied microbiology and biotechnology · 2023Article
- Characterization of BisI Homologs.Frontiers in microbiology · 2021Article
- Evolutionary Ecology and Interplay of Prokaryotic Innate and Adaptive Immune Systems.Current biology : CB · 2020Review
- Low-level expression of the Type II restriction-modification system confers potent bacteriophage resistance in Escherichia coli.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- Systematic evasion of the restriction-modification barrier in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- DNA phosphorothioate modification-a new multi-functional epigenetic system in bacteria.FEMS microbiology reviews · 2019Review
- Sampling the mobile gene pool: innovation via horizontal gene transfer in bacteria.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Restriction endonuclease triggered bacterial apoptosis as a mechanism for long time survival.Nucleic acids research · 2017Article
- Anti-Restriction Protein, KlcAFrontiers in cellular and infection microbiology · 2017Article
- Restriction-modification mediated barriers to exogenous DNA uptake and incorporation employed by Prevotella intermedia.PloS one · 2017Article
- Regulation of genetic flux between bacteria by restriction-modification systems.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Role of DNA Restriction-Modification Systems in the Biology of Bacillus anthracis.Frontiers in microbiology · 2016Review
- The EcoKI type I restriction-modification system in Escherichia coli affects but is not an absolute barrier for conjugation.Journal of bacteriology · 2015Article
- Active site plasticity enables metal-dependent tuning of Cas5d nuclease activity in CRISPR-Cas type I-C system.Nucleic acids research · 2014Article
- Increasing cleavage specificity and activity of restriction endonuclease KpnI.Nucleic acids research · 2013Article
- Naturally-occurring, dually-functional fusions between restriction endonucleases and regulatory proteins.BMC evolutionary biology · 2013Article
- Genome-scale analysis of escherichia coli FNR reveals complex features of transcription factor binding.PLoS genetics · 2013Article
- Diverse functions of restriction-modification systems in addition to cellular defense.Microbiology and molecular biology reviews : MMBR · 2013Review
- Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most bacterial genomes harbor restriction-modification systems, encoding a REase and its cognate MTase. On attack by a foreign DNA, the REase recognizes it as nonself and subjects it to restriction. Should REases be highly specific for targeting the invading foreign DNA? It is often considered to be the case. However, when bacteria harboring a promiscuous or high-fidelity variant of the REase were challenged with bacteriophages, fitness was maximal under conditions of catalytic promiscuity. We also delineate possible mechanisms by which the REase recognizes the chromosome as self at the noncanonical sites, thereby preventing lethal dsDNA breaks. This study provides a fundamental understanding of how bacteria exploit an existing defense system to gain fitness advantage during a host-parasite coevolutionary "arms race."
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.