ArticleProceedings of the National Academy of Sciences of the United States of America2012
Designing biomimetic pores based on carbon nanotubes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 88 citations in OpenAlex.
- Bio-inspired pores for selective ion transport.National science review · 2025Article
- Nanoporous Membranes of Densely Packed Carbon Nanotubes Formed by Lipid-Mediated Self-Assembly.ACS applied bio materials · 2024Review
- Article
- Anomalous water transport in narrow-diameter carbon nanotubes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Influence of effective polarization on ion and water interactions within a biomimetic nanopore.Biophysical journal · 2022Article
- Article
- Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Fast Permeation of Small Ions in Carbon Nanotubes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Water in Nanopores and Biological Channels: A Molecular Simulation Perspective.Chemical reviews · 2020Review
- The mixture effect on ionic selectivity and permeability of nanotubes.Nanoscale advances · 2020Article
- Carbon nanoparticles enhance potassium uptake via upregulating potassium channel expression and imitating biological ion channels in BY-2 cells.Journal of nanobiotechnology · 2020Article
- Water and hydrophobic gates in ion channels and nanopores.Faraday discussions · 2018Article
- Carbon nanotubes in microfluidic lab-on-a-chip technology: current trends and future perspectives.Microfluidics and nanofluidics · 2017Article
- Stability and dynamics of membrane-spanning DNA nanopores.Nature communications · 2017Article
- Highly permeable artificial water channels that can self-assemble into two-dimensional arrays.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Water transport control in carbon nanotube arrays.Nanoscale research letters · 2014Article
- Ion enrichment on the hydrophobic carbon-based surface in aqueous salt solutions due to cation-π interactions.Scientific reports · 2013Article
- Lipid nanotechnology.International journal of molecular sciences · 2013Article
- Single-stranded DNA within nanopores: conformational dynamics and implications for sequencing; a molecular dynamics simulation study.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Biomimetic nanopores based on membrane-spanning single-walled carbon nanotubes have been designed to include selectivity filters based on combinations of anionic and cationic groups mimicking those present in bacterial porins and in voltage-gated sodium and calcium channels. The ion permeation and selectivity properties of these nanopores when embedded in a phospholipid bilayer have been explored by molecular dynamics simulations and free energy profile calculations. The interactions of the nanopores with sodium, potassium, calcium, and chloride ions have been explored as a function of the number of anionic and cationic groups within the selectivity filter. Unbiased molecular dynamics simulations show that the overall selectivity is largely determined by the net charge of the filter. Analysis of distribution functions reveals considerable structuring of the distribution of ions and water within the nanopores. The distributions of ions along the pore axis reveal local selectivity for cations around filter, even in those nanopores (C0) where the net filter charge is zero. Single ion free energy profiles also reveal clear evidence for cation selectivity, even in the C0 nanopores. Detailed analysis of the interactions of the C0 nanopore with Ca(2+) ions reveals that local interactions with the anionic (carboxylate) groups of the selectivity filter lead to (partial) replacement of solvating water as the ion passes through the pore. These studies suggest that a computational biomimetic approach can be used to evaluate our understanding of the design principles of nanopores and channels.
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Registered trials
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