Trial reportBrain : a journal of neurology2012
Dopamine and performance in a reinforcement learning task: evidence from Parkinson's disease.
Trial report in Brain : a journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed.
- Moral decision making under modafinil: a randomized placebo-controlled double-blind crossover fMRI study.Psychopharmacology · 2019Trial
- Levodopa does not affect expression of reinforcement learning in older adults.Scientific reports · 2019Trial
- Dopamine Increases a Value-Independent Gambling Propensity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Dopaminergic Modulation of Decision Making and Subjective Well-Being.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Dopamine modulates the neural representation of subjective value of food in hungry subjects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Role of dopamine D2 receptors in human reinforcement learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Love to win or hate to Lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward versus punishment.Journal of cognitive neuroscience · 2014Trial
- Adaptive integration of model-based and model-free strategies in human reinforcement learning of reachable space.bioRxiv : the preprint server for biology · 2026Article
- Impaired value-based decision-making in Parkinson's disease apathy.Brain : a journal of neurology · 2024Article
- Reliability of gamified reinforcement learning in densely sampled longitudinal assessments.PLOS digital health · 2023Article
- Impulse control disorder in Parkinson's disease is associated with abnormal frontal value signalling.Brain : a journal of neurology · 2023Article
- A Brief Review on the Potential of Psychedelics for Treating Alzheimer's Disease and Related Depression.International journal of molecular sciences · 2023Review
- Article
- Gambling Environment Exposure Increases Temporal Discounting but Improves Model-Based Control in Regular Slot-Machine Gamblers.Computational psychiatry (Cambridge, Mass.) · 2022Article
- What Is Social about Autism? The Role of Allostasis-Driven Learning.Brain sciences · 2021Article
- Application of Three Ecological Assessment Tools in Examining Chromatographic Methods for the Green Analysis of a Mixture of Dopamine, Serotonin, Glutamate and GABA: A Comparative Study.Molecules (Basel, Switzerland) · 2021Article
- Rational inattention and tonic dopamine.PLoS computational biology · 2021Article
- Advances in clinical basic research: Performance, treatments, and mechanisms of Parkinson disease.Ibrain · 2021Review
- Effects of dopamine on reinforcement learning in Parkinson's disease depend on motor phenotype.Brain : a journal of neurology · 2020Article
- Corticostriatal White Matter Integrity and Dopamine D1 Receptor Availability Predict Age Differences in Prefrontal Value Signaling during Reward Learning.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The role dopamine plays in decision-making has important theoretical, empirical and clinical implications. Here, we examined its precise contribution by exploiting the lesion deficit model afforded by Parkinson's disease. We studied patients in a two-stage reinforcement learning task, while they were ON and OFF dopamine replacement medication. Contrary to expectation, we found that dopaminergic drug state (ON or OFF) did not impact learning. Instead, the critical factor was drug state during the performance phase, with patients ON medication choosing correctly significantly more frequently than those OFF medication. This effect was independent of drug state during initial learning and appears to reflect a facilitation of generalization for learnt information. This inference is bolstered by our observation that neural activity in nucleus accumbens and ventromedial prefrontal cortex, measured during simultaneously acquired functional magnetic resonance imaging, represented learnt stimulus values during performance. This effect was expressed solely during the ON state with activity in these regions correlating with better performance. Our data indicate that dopamine modulation of nucleus accumbens and ventromedial prefrontal cortex exerts a specific effect on choice behaviour distinct from pure learning. The findings are in keeping with the substantial other evidence that certain aspects of learning are unaffected by dopamine lesions or depletion, and that dopamine plays a key role in performance that may be distinct from its role in learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.