ArticleThe Journal of cell biology2012
Drosophila chibby is required for basal body formation and ciliogenesis but not for Wg signaling.
Article in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Using a female-specific isoform ofiScience · 2025Article
- A conserved role for centriolar satellites in translation of centrosomal and ciliary proteins.The Journal of cell biology · 2025Article
- Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating.Molecular biology of the cell · 2021Article
- Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis.Scientific reports · 2021Article
- Twitchy, the Drosophila orthologue of the ciliary gating protein FBF1/dyf-19, is required for coordinated locomotion and male fertility.Biology open · 2021Article
- Orbit/CLASP determines centriole length by antagonising Klp10A inJournal of cell science · 2021Article
- CEP290 is essential for the initiation of ciliary transition zone assembly.PLoS biology · 2020Article
- Article
- salto/CG13164 is required for sperm head morphogenesis in Drosophila.Molecular biology of the cell · 2019Article
- The Microtubule-Depolymerizing Kinesin-13 Klp10A Is Enriched in the Transition Zone of the Ciliary Structures ofFrontiers in cell and developmental biology · 2019Article
- Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity.Nature cell biology · 2018Article
- Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation.PLoS genetics · 2018Article
- Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.PLoS genetics · 2017Article
- The Centrioles, Centrosomes, Basal Bodies, and Cilia ofGenetics · 2017Review
- The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate.Molecules and cells · 2017Review
- How centrioles acquire the ability to reproduce.eLife · 2017Article
- Article
- Nuclear roles for cilia-associated proteins.Cilia · 2017Review
- BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis.Molecular and cellular biology · 2016Article
- Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults.Journal of cell science · 2016Article
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Authors and funding
9 authors.
Funding
Abstract
Centriole-to-basal body conversion, a complex process essential for ciliogenesis, involves the progressive addition of specific proteins to centrioles. CHIBBY (CBY) is a coiled-coil domain protein first described as interacting with β-catenin and involved in Wg-Int (WNT) signaling. We found that, in Drosophila melanogaster, CBY was exclusively expressed in cells that require functional basal bodies, i.e., sensory neurons and male germ cells. CBY was associated with the basal body transition zone (TZ) in these two cell types. Inactivation of cby led to defects in sensory transduction and in spermatogenesis. Loss of CBY resulted in altered ciliary trafficking into neuronal cilia, irregular deposition of proteins on spermatocyte basal bodies, and, consequently, distorted axonemal assembly. Importantly, cby(1/1) flies did not show Wingless signaling defects. Hence, CBY is essential for normal basal body structure and function in Drosophila, potentially through effects on the TZ. The function of CBY in WNT signaling in vertebrates has either been acquired during vertebrate evolution or lost in Drosophila.
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