ArticleMolecular psychiatry2013
Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression.
Article in Molecular psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 110 citations in OpenAlex.
- Reproductive steroid receptors and actions in the locus coeruleus of male macaques: Part of an aggression circuit?Progress in neuro-psychopharmacology & biological psychiatry · 2016Trial
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- Maturation of Micturition-Related Neural Circuits That Control Pelvic Visceromotor Functions in Postnatal Rats.The European journal of neuroscience · 2025Article
- Fear Synchrony of Mouse Dyads: Interaction of Sex Composition and Stress.Biological psychiatry global open science · 2025Article
- The Locus Coeruleus: Anatomy, Physiology, and Stress-Related Neuropsychiatric Disorders.The European journal of neuroscience · 2025Review
- Disruption of the CRFeLife · 2025Article
- Early life stress induced sex-specific changes in behavior is paralleled by altered locus coeruleus physiology in BALB/cJ mice.Neurobiology of stress · 2024Article
- Sex differences in single neuron function and proteomics profiles examined by patch-clamp and mass spectrometry in the locus coeruleus of the adult mouse.Acta physiologica (Oxford, England) · 2024Article
- Impacts of sex differences on optogenetic, chemogenetic, and calcium-imaging tools.Current opinion in neurobiology · 2024Review
- Corticotropin-releasing factor-dopamine interactions in male and female macaque: Beyond the classic VTA.Synapse (New York, N.Y.) · 2024Article
- Sex differences in hippocampal β-adrenergic receptor subtypes drive retrieval, retention, and learning of cocaine-associated memories.Frontiers in behavioral neuroscience · 2024Article
- Hindbrain Adrenergic/Noradrenergic Control of Integrated Endocrine and Autonomic Stress Responses.Endocrinology · 2023Review
- Subunit-specific expression and function of AMPA receptors in the mouse locus coeruleus.Journal of anatomy · 2023Article
- By what molecular mechanisms do social determinants impact cardiometabolic risk?Clinical science (London, England : 1979) · 2023Review
- Sex Differences in Depression and Anxiety.Current topics in behavioral neurosciences · 2023Article
- Sex differences in chronic pain-induced mental disorders: Mechanisms of cerebral circuitry.Frontiers in molecular neuroscience · 2023Review
- Sex-Related Predisposition to Post-Traumatic Stress Disorder Development-The Role of Neuropeptides.International journal of environmental research and public health · 2021Review
- Sex differences in anxiety and depression: circuits and mechanisms.Nature reviews. Neuroscience · 2021Review
- How Does Psychological Distress Due to the COVID-19 Pandemic Impact on Internet Addiction and Instagram Addiction in Emerging Adults?International journal of environmental research and public health · 2021Article
- A review of the effects of acute and chronic cannabinoid exposure on the stress response.Frontiers in neuroendocrinology · 2021Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Stress-related psychiatric disorders are more prevalent in women than men. As hypersecretion of the stress neuromediator, corticotropin-releasing factor (CRF) has been implicated in these disorders, sex differences in CRF sensitivity could underlie this disparity. Hyperarousal is a core symptom that is shared by stress-related disorders and this has been attributed to CRF regulation of the locus ceruleus (LC)-norepinephrine arousal system. We recently identified sex differences in CRF(1) receptor (CRF(1)) signaling and trafficking that render LC neurons of female rats more sensitive to CRF and potentially less able to adapt to excess CRF compared with male rats. The present study used a genetic model of CRF overexpression to test the hypothesis that females would be more vulnerable to LC dysregulation by conditions of excess CRF. In both male and female CRF overexpressing (CRF-OE) mice, the LC was more densely innervated by CRF compared with wild-type controls. Despite the equally dense CRF innervation of the LC in male and female CRF-OE mice, LC discharge rates recorded in slices in vitro were selectively elevated in female CRF-OE mice. Immunoelectron microscopy revealed that this sex difference resulted from differential CRF(1) trafficking. In male CRF-OE mice, CRF(1) immunolabeling was prominent in the cytoplasm of LC neurons, indicative of internalization, a process that would protect cells from excessive CRF. However, in female CRF-OE mice, CRF(1) labeling was more prominent on the plasma membrane, suggesting that the compensatory response of internalization was compromised. Together, the findings suggest that the LC-norepinephrine system of females will be particularly affected by conditions resulting in elevated CRF because of differences in receptor trafficking. As excessive LC activation has been implicated in the arousal components of stress-related psychiatric disorders, this may be a cellular mechanism that contributes to the increased incidence of these disorders in females.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.