SynthesisArthritis and rheumatism2012
Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.
Synthesis in Arthritis and rheumatism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population.Journal of human genetics · 2018Trial
- Potential impact of two functional variants in theCaspian journal of internal medicine · 2026Article
- Targeting immune checkpoints in anti-neutrophil cytoplasmic antibodies associated vasculitis: the potential therapeutic targets in the future.Frontiers in immunology · 2023Review
- Hypothyroidism in vasculitis.Rheumatology (Oxford, England) · 2022Article
- Mechanisms of vascular damage in ANCA vasculitis.Seminars in immunopathology · 2022Review
- Anti-neutrophil cytoplasmic antibody associated vasculitis in patients with rheumatoid arthritis.BMC nephrology · 2022Observational
- Peripheral ulcerative keratitis, nodular episcleritis, and pulmonary nodules as the initial signs of rheumatic arthritis: A Case Report.Frontiers in immunology · 2022Article
- Article
- Advances in the genomics of ANCA-associated vasculitis-a view from East Asia.Genes and immunity · 2021Review
- Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review.Journal of clinical medicine · 2019Article
- Novel insights into the aetiology of granulomatosis with polyangiitis-a case-control study using the Clinical Practice Research Datalink.Rheumatology (Oxford, England) · 2018Article
- ANCA-associated vasculitis with renal involvement.Journal of nephrology · 2018Review
- Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex.Nature immunology · 2017Article
- ANCA-associated vasculitis - clinical utility of using ANCA specificity to classify patients.Nature reviews. Rheumatology · 2016Review
- Biological Therapy-Induced Systemic Vasculitis.Current rheumatology reports · 2016Review
- Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis.Journal of advanced research · 2016Review
- Genetic Susceptibility to ANCA-Associated Vasculitis: State of the Art.Frontiers in immunology · 2014Review
- Association of IRF5 polymorphism with MPO-ANCA-positive vasculitis in a Japanese population.Genes and immunity · 2013Article
- Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.Arthritis and rheumatism · 2013Article
Corrections and comments
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Authors and funding
18 authors at 10 institutions in 3 countries.
Funding
Abstract
objectiveTo examine the association of previously identified autoimmune disease susceptibility loci with granulomatosis with polyangiitis (Wegener's) (GPA), and to determine whether the genetic susceptibility profiles of other autoimmune diseases are associated with those of GPA.
methodsGenetic data from 2 cohorts were meta-analyzed. Genotypes for 168 previously identified single-nucleotide polymorphisms (SNPs) associated with susceptibility to different autoimmune diseases were ascertained in a total of 880 patients with GPA and 1,969 control subjects of European descent. Single-marker associations were identified using additive logistic regression models. Associations of multiple SNPs with GPA were assessed using genetic risk scores based on susceptibility loci for Crohn's disease, type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis (RA), celiac disease, and ulcerative colitis. Adjustment for population substructure was performed in all analyses, using ancestry-informative markers and principal components analysis.
resultsGenetic polymorphisms in CTLA4 were significantly associated with GPA in the single-marker meta-analysis (odds ratio [OR] 0.79, 95% confidence interval [95% CI] 0.70-0.89, P = 9.8 × 10(-5) ). The genetic risk score for RA susceptibility markers was significantly associated with GPA (OR 1.05 per 1-unit increase in genetic risk score, 95% CI 1.02-1.08, P = 5.1 × 10(-5) ).
conclusionRA and GPA may arise from a similar genetic predisposition. Aside from CTLA4, other loci previously found to be associated with common autoimmune diseases were not statistically significantly associated with GPA in this study.
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