ArticleAntimicrobial agents and chemotherapy2012
In vitro anti-Trypanosoma cruzi activity of dronedarone, a novel amiodarone derivative with an improved safety profile.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Dronedarone synergizes with colistin against planktonic and biofilm forms of multidrug-resistant Gram-negative pathogens.Microbiology spectrum · 2026Article
- Chagas disease and amiodarone: a bibliometric and systematic review from cell to patient.Frontiers in pharmacology · 2026Review
- Effects of amiodarone, amioder, and dronedarone on Trichomonas vaginalis.Parasitology research · 2022Article
- Article
- SQ109 inhibits proliferation of Leishmania donovani by disruption of intracellular CaParasitology research · 2020Article
- Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target AgainstFrontiers in cellular and infection microbiology · 2020Review
- Precision Health for Chagas Disease: Integrating Parasite and Host Factors to Predict Outcome of Infection and Response to Therapy.Frontiers in cellular and infection microbiology · 2020Review
- Mechanism of Action of Miltefosine on Leishmania donovani Involves the Impairment of Acidocalcisome Function and the Activation of the Sphingosine-Dependent Plasma Membrane CaAntimicrobial agents and chemotherapy · 2018Article
- Experimental and Clinical Treatment of Chagas Disease: A Review.The American journal of tropical medicine and hygiene · 2017Review
- Differential cytokine profiling in Chagasic patients according to their arrhythmogenic-status.BMC infectious diseases · 2017Article
- Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109.Antimicrobial agents and chemotherapy · 2016Article
- SQ109, a new drug lead for Chagas disease.Antimicrobial agents and chemotherapy · 2015Article
- Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective.Frontiers in pharmacology · 2015Article
- Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy.Antimicrobial agents and chemotherapy · 2014Article
- Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation.Clinical Medicine Insights. Cardiology · 2013Article
- Diagnosis and management of Chagas disease and cardiomyopathy.Nature reviews. Cardiology · 2012Review
- The emerging role of amiodarone and dronedarone in Chagas disease.Nature reviews. Cardiology · 2012Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amiodarone, a commonly used antiarrhythmic, is also a potent and selective anti-Trypanosoma cruzi agent. Dronedarone is an amiodarone derivative in which the 2,5-diiodophenyl moiety of the parental drug has been replaced with an unsubstituted phenyl group aiming to eliminate the thyroid toxicity frequently observed with amiodarone treatment. Dronedarone has been approved by the Food and Drug Administration (FDA), and its use as a safe antiarrhythmic has been extensively documented. We show here that dronedarone also has potent anti-T. cruzi activity, against both extracellular epimastigotes and intracellular amastigotes, the clinically relevant form of the parasite. The 50% inhibitory concentrations against both proliferative stages are lower than those previously reported for amiodarone. The mechanism of action of dronedarone resembles that of amiodarone, as it induces a large increase in the intracellular Ca(2+) concentration of the parasite, which results from the release of this ion from intracellular storage sites, including a direct effect of the drug on the mitochondrial electrochemical potential, and through alkalinization of the acidocalcisomes. Our results suggest a possible future repurposed use of dronedarone for the treatment of Chagas' disease.
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