ArticleEnvironmental research2012
The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice.
Article in Environmental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Effects of inhaled tier-2 diesel engine exhaust on immunotoxicity in a rat model: A hazard identification study. Part II. Immunotoxicology.Toxicology reports · 2024Article
- Evaluation of Apical and Molecular Effects of AlgaeToxics · 2023Article
- Dietary Intervention with Blackcurrant Pomace Protects Rats from Testicular Oxidative Stress Induced by Exposition to Biodiesel Exhaust.Antioxidants (Basel, Switzerland) · 2022Article
- Indirect mediators of systemic health outcomes following nanoparticle inhalation exposure.Pharmacology & therapeutics · 2022Review
- miR-99 family is potential target to reverse cerium dioxide nanoparticle-induced placental cell dysfunction.Annals of translational medicine · 2022Article
- Combined Toxicity of Metal Nanoparticles: Comparison of Individual and Mixture Particles Effect.Advances in experimental medicine and biology · 2021Article
- Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease.Neurochemistry international · 2020Article
- Vehicular Particulate Matter (PM) Characteristics Impact Vascular Outcomes Following Inhalation.Cardiovascular toxicology · 2020Article
- Pulmonary toxicity of inhaled nano-sized cerium oxide aerosols in Sprague-Dawley rats.Nanotoxicology · 2019Article
- Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series.Journal of the American College of Cardiology · 2017Review
- The acute pulmonary and thrombotic effects of cerium oxide nanoparticles after intratracheal instillation in mice.International journal of nanomedicine · 2017Article
- In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats.Particle and fibre toxicology · 2016Article
- The Apoe(-/-) mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction.Journal of translational medicine · 2016Review
- Effects of amorphous silica coating on cerium oxide nanoparticles induced pulmonary responses.Toxicology and applied pharmacology · 2015Article
- Inhaled diesel emissions generated with cerium oxide nanoparticle fuel additive induce adverse pulmonary and systemic effects.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- The Yin: An adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity.Environmental science. Nano · 2014Article
- Interactive effects of cerium oxide and diesel exhaust nanoparticles on inducing pulmonary fibrosis.Toxicology and applied pharmacology · 2014Article
- Comparative pulmonary toxicity of two ceria nanoparticles with the same primary size.International journal of molecular sciences · 2014Article
- Variability in bioreactivity linked to changes in size and zeta potential of diesel exhaust particles in human immune cells.PloS one · 2014Article
- Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice.Particle and fibre toxicology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundCerium oxide (CeO(2)) nanoparticles improve the burning efficiency of fuel, however, little is known about health impacts of altered emissions from the vehicles.
methodsAtherosclerosis-prone apolipoprotein E knockout (ApoE(-/-)) mice were exposed by inhalation to diluted exhaust (1.7 mg/m(3), 20, 60 or 180 min, 5 day/week, for 4 weeks), from an engine using standard diesel fuel (DE) or the same diesel fuel containing 9 ppm cerium oxide nanoparticles (DCeE). Changes in hematological indices, clinical chemistry, atherosclerotic burden, tissue levels of inflammatory cytokines and pathology of the major organs were assessed.
resultsAddition of CeO(2) to fuel resulted in a reduction of the number (30%) and surface area (10%) of the particles in the exhaust, whereas the gaseous co-pollutants were increased (6-8%). There was, however, a trend towards an increased size and complexity of the atherosclerotic plaques following DE exposure, which was not evident in the DCeE group. There were no clear signs of altered hematological or pathological changes induced by either treatment. However, levels of proinflammatory cytokines were modulated in a brain region and liver following DCeE exposure.
conclusionsThese results imply that addition of CeO(2) nanoparticles to fuel decreases the number of particles in exhaust and may reduce atherosclerotic burden associated with exposure to standard diesel fuel. From the extensive assessment of biological parameters performed, the only concerning effect of cerium addition was a slightly raised level of cytokines in a region of the central nervous system. Overall, the use of cerium as a fuel additive may be a potentially useful way to limit the health effects of vehicle exhaust. However, further testing is required to ensure that such an approach is not associated with a chronic inflammatory response which may eventually cause long-term health effects.
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