Evidence map›Paper›PMID 22507897›Full record

ArticleEpigenetics2012

Virion-mediated transfer of SV40 epigenetic information.

Barry Milavetz, Les Kallestad, Amanda Gefroh, Nicholas Adams, Emily Woods, Lata Balakrishnan

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Mapping Nucleosome Location Using FS-Seq.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Epigenetic Analysis of SV40 Minichromosomes.Current protocols in microbiology · 2017
    Article
  9. Article
  10. Article
  11. Viral epigenetics.Methods in molecular biology (Clifton, N.J.) · 2015
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Barry MilavetzDepartment of Biochemistry and Molecular Biology; University of North Dakota, Grand Forks, ND, USA. bmilavetz@medicine.nodak.edu
Les Kallestad
Amanda Gefroh
Nicholas Adams
Emily Woods
Lata Balakrishnan
University of North Dakota · US

Funding

Hyperacetylation of Biologically Active SV40 ChromatinR15GM074811 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI MILAVETZ, BARRY I · 2006 to 2006
$209k
HISTONE HYPERACETYLATION IN REPLICATING SV40 CHROMOSOMESR03AI070193 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI MILAVETZ, BARRY IRA · 2008 to 2009
$135k
NIAID NIH HHS AI070193NIAID NIH HHS R03 AI070193NIGMS NIH HHS GM074811NIGMS NIH HHS R15 GM074811
6 · The paper itself

Abstract

In eukaryotes, epigenetic information can be encoded in parental cells through modification of histones and subsequently passed on to daughter cells in a process known as transgenerational epigenetic regulation. Simian Virus 40 (SV40) is a well-characterized virus whose small circular DNA genome is organized into chromatin and, as a consequence, undergoes many of the same biological processes observed in cellular chromatin. In order to determine whether SV40 is capable of transgenerational epigenetic regulation, we have analyzed SV40 chromatin from minichromosomes and virions for the presence of modified histones using various ChIP techniques and correlated these modifications with specific biological effects on the SV40 life cycle. Our results demonstrate that, like its cellular counterpart, SV40 chromatin is capable of passing biologically relevant transgenerational epigenetic information between infections.

Indexed as

Epigenesis, GeneticAnimalsCell LineChromatinChromatin ImmunoprecipitationHistonesProtein Processing, Post-TranslationalSimian virus 40Viral Nonstructural ProteinsVirionChromatinHistonesViral Nonstructural Proteins

Identifiers

PMID22507897
PMCPMC3398982
OpenAlexW2083228706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.