Evidence map›Paper›PMID 22506671›Full record

ArticleOrganic letters2012

Palladium-catalyzed asymmetric allylic alkylation of electron-deficient pyrroles with meso electrophiles.

Barry M Trost, Maksim Osipov, Guangbin Dong

Abstract read
In one paragraph

Article in Organic letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Barry M TrostDepartment of Chemistry, Stanford University, Stanford, California 94305, United States. bmtrost@stanford.edu
Maksim Osipov
Guangbin Dong

Funding

NOVEL SYNTHETIC APPROACHES TO ANTITUMOR COMPOUNDSR01GM033049 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI TROST, BARRY M · 1985 to 2016
$6.5M
NIGMS NIH HHS GM33049NIGMS NIH HHS R01 GM033049
6 · The paper itself

Abstract

Pyrroles can serve as competent nucleophiles with meso electrophiles in the Pd-catalyzed asymmetric allylic alkylation. The products from this transformation were obtained as a single regio- and diastereomer in high yield and enantiopurity. A nitropyrrole-containing nucleoside analogue was synthesized in seven steps to demonstrate the synthetic utility of this transformation.

Indexed as

AlkylationAllyl CompoundsCatalysisMolecular StructureNucleosidesPalladiumPyrrolesStereoisomerismAllyl CompoundsNucleosidesPalladiumPyrroles

Identifiers

PMID22506671
PMCPMC3407807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.