ArticleJournal of aging research2012
Age-related loss of muscle mass and strength.
Article in Journal of aging research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Low-dose baclofen therapy raised plasma insulin-like growth factor-1 concentrations, but not into the normal range in a predictable and sustained manner in men with chronic spinal cord injury.The journal of spinal cord medicine · 2013Trial
- Comparative effects of single vs. multiple-set resistance training on neuromuscular performance and muscle morphology in sedentary men.BMC sports science, medicine & rehabilitation · 2026Article
- Patterns of Muscle Health in Single- and Multi-Site Chronic Pain: A UK Biobank Normative Modeling Study.medRxiv : the preprint server for health sciences · 2026Article
- Orthodontic treatment and musculoskeletal balance: a cross-sectional study of postural and functional outcomes in young adults.BMC oral health · 2025Article
- Adaptations in mitochondrial quality control and interactions with innate immune signaling within skeletal muscle: A narrative review.Journal of sport and health science · 2025Review
- Article
- The effect of advanced age and stool modification on reaching distance in sitting.Journal of physical therapy science · 2024Article
- Motor Performance and Skill Acquisition in Oral Motor Training With Exergames: A Pilot Study.Frontiers in aging neuroscience · 2022Article
- Association of muscular fitness with rehospitalization for heart failure with reduced ejection fraction.Clinical cardiology · 2021Article
- Sinensetin regulates age-related sarcopenia in cultured primary thigh and calf muscle cells.BMC complementary and alternative medicine · 2019Article
- Strengthening the Brain-Is Resistance Training with Blood Flow Restriction an Effective Strategy for Cognitive Improvement?Journal of clinical medicine · 2018Article
- A Mini Review of Using the Oralift Appliance and a Pilot Study to See if 3D Imaging Techniques Could Improve Outcomes.The open dentistry journal · 2018Review
- Diet Modeling in Older Americans: The Impact of Increasing Plant-Based Foods or Dairy Products on Protein Intake.The journal of nutrition, health & aging · 2017Article
- Effects of age and hindlimb immobilization and remobilization on fast troponin T precursor mRNA alternative splicing in rat gastrocnemius muscle.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016Article
- Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice.Bone · 2015Article
- Mechano growth factor-E regulates apoptosis and inflammatory responses in fibroblast-like synoviocytes of knee osteoarthritis.International orthopaedics · 2015Article
- Influence of ageing and essential amino acids on quantitative patterns of troponin T alternative splicing in human skeletal muscle.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2015Article
- Intense Walking Exercise Affects Serum IGF-1 and IGFBP3.Journal of lifestyle medicine · 2015Article
- An overview of structure, mechanical properties, and treatment for age-related tendinopathy.The journal of nutrition, health & aging · 2014Review
- Sonic hedgehog therapy in a mouse model of age-associated impairment of skeletal muscle regeneration.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Age-related muscle wasting and increased frailty are major socioeconomic as well as medical problems. In the quest to extend quality of life it is important to increase the strength of elderly people sufficiently so they can carry out everyday tasks and to prevent them falling and breaking bones that are brittle due to osteoporosis. Muscles generate the mechanical strain that contributes to the maintenance of other musculoskeletal tissues, and a vicious circle is established as muscle loss results in bone loss and weakening of tendons. Molecular and proteomic approaches now provide strategies for preventing age-related muscle wasting. Here, attention is paid to the role of the GH/IGF-1 axis and the special role of the IGFI-Ec (mechano growth factor/MGF) which is derived from the IGF-I gene by alternative splicing. During aging MGF levels decline but when administered MGF activates the muscle satellite (stem) cells that "kick start" local muscle repair and induces hypertrophy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.