ArticlePloS one2012
Increase in cerebellar volume in Cavalier King Charles Spaniels with Chiari-like malformation and its role in the development of syringomyelia.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- MRI-derived three-dimensional modelling reveals cervicothoracic subarachnoid space narrowing in syringomyelia-affected cavalier king charles spaniels.BMC veterinary research · 2026Article
- Hearing assessment in Pomeranian dogs with and without Chiari-like malformation based on brainstem auditory evoked response wave latencies.Frontiers in veterinary science · 2026Article
- Chiari-like Malformation and Syringomyelia in Pomeranians: A Longitudinal Study.Veterinary sciences · 2025Article
- The Effectiveness of Amitriptyline and Gabapentin in Treating Pomeranians with Chiari-like Malformation and/or Syringomyelia.Animals : an open access journal from MDPI · 2025Article
- CT- and MRI-based volumetry for Chiari-like malformation and syringomyelia in Pomeranians.Frontiers in veterinary science · 2025Article
- The effect of MRI-based screening and selection on the prevalence of syringomyelia in the Dutch and Danish Cavalier King Charles Spaniels.Frontiers in veterinary science · 2024Article
- Surgical modeling of Chiari-like malformation in rats: Insights from canine morphology.PloS one · 2024Article
- Decoding Chiari Malformation and Syringomyelia: From Epidemiology and Genetics to Advanced Diagnosis and Management Strategies.Brain sciences · 2023Review
- Reduced cingulate gyrus volume in Cavalier King Charles Spaniels with syringomyelia and neuropathic pain revealed by voxel-based morphometry: a pilot study.Frontiers in neuroanatomy · 2023Article
- On the importance of integrating comparative anatomy and One Health perspectives in anatomy education.Journal of anatomy · 2022Review
- Biopsy and histologic findings of the dura mater at the level of the foramen magnum in 121 CKCS with Chiari-like malformation.Frontiers in veterinary science · 2022Article
- The Need for Head Space: Brachycephaly and Cerebrospinal Fluid Disorders.Life (Basel, Switzerland) · 2021Review
- Using machine learning to understand neuromorphological change and image-based biomarker identification in Cavalier King Charles Spaniels with Chiari-like malformation-associated pain and syringomyelia.Journal of veterinary internal medicine · 2019Article
- Consequences and Management of Canine Brachycephaly in Veterinary Practice: Perspectives from Australian Veterinarians and Veterinary Specialists.Animals : an open access journal from MDPI · 2018Review
- A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels.BMC genetics · 2018Article
- Clinical Application of Diagnostic Imaging of Chiari-Like Malformation and Syringomyelia.Frontiers in veterinary science · 2018Review
- Morphogenesis of Canine Chiari Malformation and Secondary Syringomyelia: Disorders of Cerebrospinal Fluid Circulation.Frontiers in veterinary science · 2018Review
- Syringomyelia and Craniocervical Junction Abnormalities in Chihuahuas.Journal of veterinary internal medicine · 2017Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Previous research in Cavalier King Charles Spaniels (CKCS) has found that Chiari-like malformation and syringomyelia (CM/SM) are associated with a volume mismatch between the caudal cranial fossa (CCF) and the brain parenchyma contained within. The objectives of this study were to i) compare cerebellar volume in CKCS (a "high risk' group which frequently develops CM/SM), small breed dogs (medium risk--occasionally develop CM/SM), and Labradors (low risk--CM/SM not reported); ii) evaluate a possible association between increased cerebellar volume and CM/SM in CKCS; iii) investigate the relationship between increased cerebellar volume and crowding of the cerebellum in the caudal part of the CCF (i.e. the region of the foramen magnum). Volumes of three-dimensional, magnetic resonance imaging derived models of the CCF and cerebellum were obtained from 75 CKCS, 44 small breed dogs, and 31 Labradors. As SM is thought to be a late onset disease process, two subgroups were formed for comparison: 18 CKCS younger than 2 years with SM (CM/SM group) and 13 CKCS older than 5 years without SM (CM group). Relative cerebellar volume was defined as the volume of the cerebellum divided by the total volume of brain parenchyma. Our results show that the CKCS has a relatively larger cerebellum than small breed dogs and Labradors and provide evidence that increased cerebellar volume in CKCS is associated with crowding of cerebellum in the caudal part of the CCF. In CKCS there is an association between increased cerebellar volume and SM. These findings have implications for the understanding of the pathological mechanisms of CM/SM, and support the hypothesis that it is a multifactorial disease process governed by increased cerebellar volume and failure of the CCF to reach a commensurate size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.