Evidence map›Paper›PMID 22505864›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2012

Nighttime awakenings responding to gabapentin therapy in late premenopausal women: a case series.

Thomas Guttuso

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Gabapentin efficacy in reducing nighttime awakenings in premenopausal women: a class effect of GABAergic medications or unique property of gabapentin only?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2012
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Thomas GuttusoDepartment of Neurology, University at Buffalo, Buffalo, NY 14214, USA. tguttuso@buffalo.edu
University at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insomnia related to nighttime awakenings is known to be more prevalent in women than men. Three cases are presented here of late premenopausal women experiencing frequent nighttime awakenings that responded well to bedtime treatment with gabapentin. In one case, what started as isolated nighttime awakenings slowly progressed to awakenings accompanied by typical menopausal night sweats. This led to the theory that the initial isolated nighttime awakenings in this patient may have been secondary to a menopausal etiology related to low serum estradiol levels. In the subsequent 2 cases, early follicular phase serum estradiol was confirmed to be low. It is theorized that isolated nighttime awakenings in some premenopausal women may be caused by low serum estradiol, triggering events physiologically related to menopausal night sweats. Further research is needed to determine if low early follicular phase serum estradiol is associated with nighttime awakenings in premenopausal women not experiencing night sweats.

Indexed as

AdultAminesAnti-Anxiety AgentsCyclohexanecarboxylic AcidsEstradiolFemaleFollicle Stimulating HormoneGabapentingamma-Aminobutyric AcidHumansLuteinizing HormoneMiddle AgedPremenopauseSleep Initiation and Maintenance DisordersSweatingAminesAnti-Anxiety AgentsCyclohexanecarboxylic AcidsEstradiolFollicle Stimulating HormoneGabapentingamma-Aminobutyric AcidLuteinizing Hormoneawakeningsestradiolhot flashInsomniamenopausenight sweat

Identifiers

PMID22505864
PMCPMC3311416
OpenAlexW2011870335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.