ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2012
Sleep apnea is related to the atherogenic phenotype, lipoprotein subclass B.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases.International journal of molecular sciences · 2023Review
- Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia.Biomedicines · 2022Review
- Metabolic syndrome prevalence in patients with obstructive sleep apnea syndrome and chronic obstructive pulmonary disease: Relationship with systemic inflammation.The clinical respiratory journal · 2020Article
- Obstructive Sleep Apnea Phenotypes and Markers of Vascular Disease: A Review.Frontiers in neurology · 2017Review
- Clinical manifestations of sleep apnea.Journal of thoracic disease · 2015Review
- Abnormalities of lipoprotein concentrations in obstructive sleep apnea are related to insulin resistance.Sleep · 2015Article
- Traditional and nontraditional cardiovascular risk factors in comorbid insomnia and sleep apnea.Sleep · 2014Article
- Pathobiology of obstructive sleep apnea-related dyslipidemia: focus on the liver.ISRN cardiology · 2013Article
- Sleep status and low-density lipoprotein particle size in a general Japanese female population: the MIMA study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesSleep apnea has been implicated as an independent risk factor for atherosclerotic coronary artery disease (CAD). An association between the severity of sleep apnea and total cholesterol levels has previously been reported. However, the association with small dense low density lipoprotein (LDL) cholesterol concentration (subclass B), one of the strongest predictors of atherosclerosis, is unknown. We examined the relationship between sleep apnea and LDL subclass B, considering body size.
methodsThis is a cross-sectional observational cohort of participants enrolled in a cardiovascular health study. Sleep apnea was assessed with a validated portable monitor. Lipid panels included total cholesterol, triglycerides, high density lipoprotein cholesterol, LDL cholesterol, and LDL subclasses A, B, and A/B. Sleep apnea was analyzed categorically using the apnea hypopnea index (AHI).
resultsA total of 519 participants were evaluated. Mean age was 58.7 ± 7.4 years; BMI was 29.6 ± 5.7; 65% were female; 59% were Caucasian, and 37% were African American. Among participants with abnormal waist circumference by ATP III criteria, moderate to severe sleep apnea (AHI ≥ 25) was not independently associated with LDL subclass B. In contrast, among participants with normal waist circumference, moderate to severe sleep apnea was associated with 4.5-fold odds of having LDL subclass B.
conclusionsSleep apnea is independently associated with an atherogenic phenotype (LDL subclass B) in non-obese individuals. The association between sleep apnea and LDL subclass B in those with normal waist circumference may account, in part, for the increased risk of atherosclerosis and subsequent vascular events.
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