ArticleJournal of biomedicine & biotechnology2012
Physical properties and biocompatibility of a core-sheath structure composite scaffold for bone tissue engineering in vitro.
Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Low-temperature deposition manufacturing technology: a novel 3D printing method for bone scaffolds.Frontiers in bioengineering and biotechnology · 2023Review
- Review
- Combination of polyglycerol sebacate coated with collagen for vascular engineering.Journal of cardiovascular and thoracic research · 2022Article
- 3D Composite Bioprinting for Fabrication of Artificial Biological Tissues.International journal of bioprinting · 2021Review
- Cell sheets of co-cultured BMP-2-modified bone marrow stromal cells and endothelial progenitor cells accelerate bone regenerationExperimental and therapeutic medicine · 2019Article
- A 3D-Printed PLCL Scaffold Coated with Collagen Type I and Its Biocompatibility.BioMed research international · 2018Article
- α-hemihydrate calcium sulfate/octacalcium phosphate combined with sodium hyaluronate promotes bone marrow-derived mesenchymal stem cell osteogenesis in vitro and in vivo.Drug design, development and therapy · 2018Article
- The Role of Skeletal Stem Cells in the Reconstruction of Bone Defects.The Journal of craniofacial surgery · 2017Review
- Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold.PloS one · 2016Article
- Bacterial inhibition potential of 3D rapid-prototyped magnesium-based porous composite scaffolds--an in vitro efficacy study.Scientific reports · 2015Article
- Collagen/Beta-Tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal Processing.BioMed research international · 2015Article
- Scaffold design for bone regeneration.Journal of nanoscience and nanotechnology · 2014Review
- The impact of compact layer in biphasic scaffold on osteochondral tissue engineering.PloS one · 2013Article
- The study on biocompatibility of porous nHA/PLGA composite scaffolds for tissue engineering with rabbit chondrocytes in vitro.BioMed research international · 2013Article
- Rapid prototyping technology and its application in bone tissue engineering.Journal of Zhejiang University. Science. BReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scaffolds play a critical role in the practical realization of bone tissue engineering. The purpose of this study was to assess whether a core-sheath structure composite scaffold possesses admirable physical properties and biocompatibility in vitro. A novel scaffold composed of poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PLGA/β-TCP) skeleton wrapped with Type I collagen via low-temperature deposition manufacturing (LDM) was prepared, and bone mesenchymal stem cells (BMSCs) were used to evaluate cell behavior on the scaffold. PLGA/β-TCP skeleton was chosen as the control group. Physical properties were evaluated by pority ratio, compressive strength, and Young's modulus. Scanning electron microscope (SEM) was used to study morphology of cells. Hydrophilicity was evaluated by water absorption ratio. Cell proliferation was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay (MTT). Osteogenic differentiation of BMSCs was evaluated by alkaline phosphates activity (ALP). The results indicated that physical properties of the novel scaffold were as good as those of the control group, hydrophilicity was observably better (P < 0.01) than that of control group, and abilities of proliferation and osteogenic differentiation of BMSCs on novel scaffold were significantly greater (P < 0.05) than those of control group, which suggests that the novel scaffold possesses preferable characteristics and have high value in bone tissue engineering.
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