ArticleJournal of cell science2012
Cadherin point mutations alter cell sorting and modulate GTPase signaling.
Article in Journal of cell science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Cadherins and growth factor receptors - ligand-selective mechano-switches at cadherin junctions.Journal of cell science · 2025Article
- Advances in mechanotransduction and sonobiology: effects of audible acoustic waves and low-vibration stimulations on mammalian cells.Biophysical reviews · 2024Review
- Article
- P120 catenin potentiates constitutive E-cadherin dimerization at the plasma membrane and regulates trans binding.Current biology : CB · 2021Article
- Harnessing Mechanobiology for Tissue Engineering.Developmental cell · 2021Review
- Article
- Article
- VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism.The Journal of cell biology · 2019Article
- Biophysical Tools to Study Cellular Mechanotransduction.Bioengineering (Basel, Switzerland) · 2017Review
- E-cadherin-mediated force transduction signals regulate global cell mechanics.Journal of cell science · 2016Article
- Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions.Scientific reports · 2016Article
- Radial Glial Cell-Neuron Interaction Directs Axon Formation at the Opposite Side of the Neuron from the Contact Site.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Allosteric Regulation of E-Cadherin Adhesion.The Journal of biological chemistry · 2015Article
- Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers.Journal of cell science · 2015Article
- Lateral assembly of N-cadherin drives tissue integrity by stabilizing adherens junctions.Journal of the Royal Society, Interface · 2015Article
- Sorting out a promiscuous superfamily: towards cadherin connectomics.Trends in cell biology · 2014Review
- Cadherin recognition and adhesion.Current opinion in cell biology · 2012Review
- Cadherin-dependent mechanotransduction depends on ligand identity but not affinity.Journal of cell science · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
This study investigated the impact of cadherin binding differences on both cell sorting and GTPase activation. The use of N-terminal domain point mutants of Xenopus C-cadherin enabled us to quantify binding differences and determine their effects on cadherin-dependent functions without any potential complications arising as a result of differences in cytodomain interactions. Dynamic cell-cell binding measurements carried out with the micropipette manipulation technique quantified the impact of these mutations on the two-dimensional binding affinities and dissociation rates of cadherins in the native context of the cell membrane. Pairwise binding affinities were compared with in vitro cell-sorting specificity and ligation-dependent GTPase signaling. Two-dimensional affinity differences greater than five-fold correlated with cadherin-dependent in vitro cell segregation, but smaller differences failed to induce cell sorting. Comparison of the binding affinities with GTPase signaling amplitudes further demonstrated that differential binding also proportionally modulates intracellular signaling. These results show that differential cadherin affinities have broader functional consequences than merely controlling cell-cell cohesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.