ArticleHeart (British Cardiac Society)2012
Clinical usefulness of the metabolic syndrome for the risk of coronary heart disease does not exceed the sum of its individual components in older men and women. The Three-City (3C) Study.
Article in Heart (British Cardiac Society), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Efficacy and safety of nicorandil on perioperative myocardial injury in patients undergoing elective percutaneous coronary intervention: results of the PENMIPCI trial.Drug design, development and therapy · 2018Trial
- A multifunctional diet improves cardiometabolic-related biomarkers independently of weight changes: an 8-week randomized controlled intervention in healthy overweight and obese subjects.European journal of nutrition · 2016Trial
- Lung function in elderly subjects with metabolic syndrome and type II diabetes : Data from the Berlin Aging Study II.Zeitschrift fur Gerontologie und Geriatrie · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Metabolic syndrome and cognitive deficits in the Greek cohort of Epirus Health Study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- Association of Metabolic Syndrome and Its Components with Survival of Older Adults.International journal of endocrinology and metabolism · 2020Article
- Thai CV Risk Score and Primary Prevention in Impaired Fasting Plasma Glucose or Diabetes Mellitus versus Normoglycemia in Patients with Metabolic Syndrome.International journal of preventive medicine · 2020Article
- Metabolic Syndrome Including Glycated Hemoglobin A1c in Adults: Is It Time to Change?Journal of clinical medicine · 2019Article
- Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.Circulation · 2017Review
- Which Components of Metabolic Syndrome have a Greater Effect on Mortality, CVA and Myocardial Infarction, Hyperglycemia, High Blood Pressure or Both?Advanced biomedical research · 2017Article
- Metabolic syndrome is independently associated with increased 20-year mortality in patients with stable coronary artery disease.Cardiovascular diabetology · 2016Article
- [Pulmonary function in elderly subjects with metabolic syndrome and type II diabetes : Data from the Berlin Aging Study II].Zeitschrift fur Gerontologie und Geriatrie · 2016Article
- The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: the Rotterdam study.Cardiovascular diabetology · 2016Article
- Influence of age on the prevalence and components of the metabolic syndrome and the association with cardiovascular disease.BMJ open diabetes research & care · 2016Article
- Insulin resistance and systemic inflammation, but not metabolic syndrome phenotype, predict 9 years mortality in older adults.Atherosclerosis · 2014Article
- Added value of different metabolic syndrome definitions for predicting cardiovascular disease and mortality events among elderly population: Tehran Lipid and Glucose Study.European journal of clinical nutrition · 2014Article
- Heart disease and stroke statistics--2014 update: a report from the American Heart Association.Circulation · 2014Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the respective associations and clinical usefulness of the metabolic syndrome (MetS) and its individual components to predict the risk of first coronary heart disease (CHD) events in elderly.
designThe Three-City is a French prospective multisite community-based cohort.
settingThree large French cities: Bordeaux, Dijon and Montpellier.
participants7612 subjects aged 65 and over who were free of CHD at baseline.
main outcome measuresThe MetS was defined by the 2005 National Cholesterol Education Program Adult Treatment Panel III criteria.
resultsDuring a median follow-up of 5.2 years, 275 first CHD events were adjudicated. The MetS was associated with increased risks of total (adjusted HR: 1.78; 95% CI 1.39 to 2.28), fatal (HR: 2.40; 95% CI 1.41 to 4.09) and non-fatal (HR: 1.64; 95% CI 1.24 to 2.17) CHD events. The association with total CHD was significant in women (HR: 2.56; 95% CI 1.75 to 3.75) but not in men (HR: 1.39; 95% CI 0.99 to 1.94; p for interaction=0.012). When in the same multivariable model, hyperglycemia and abdominal adiposity in women, hyperglycemia, lower HDL cholesterol and abdominal adiposity (inverse association) in men were the components significantly associated with CHD. The components of the MetS but not the MetS itself improved risk prediction beyond traditional risk factors (NRI= 9.35%, p<0;001).
conclusionThe MetS is a risk marker for CHD in community-dwelling elderly subjects but may not be useful for CHD risk prediction purposes compared to its individual components.
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