ArticleEukaryotic cell2012
Insight into the antiadhesive effect of yeast wall protein 1 of Candida albicans.
Article in Eukaryotic cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 45 citations in OpenAlex.
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- Fungal biofilms in human health and disease.Nature reviews. Microbiology · 2025Review
- Fungal biofilm formation and its regulatory mechanism.Heliyon · 2024Review
- Mechanisms of antifungal resistance and developments in alternative strategies to combat Candida albicans infection.Archives of microbiology · 2024Review
- Sinefungin, a natural nucleoside analog of S-adenosyl methionine, impairs the pathogenicity ofnpj antimicrobials and resistance · 2024Article
- Inhibitory effects of vaginalFrontiers in cellular and infection microbiology · 2023Article
- Host's Immunity andMicroorganisms · 2022Review
- Observational
- A novel class of Candida glabrata cell wall proteins with β-helix fold mediates adhesion in clinical isolates.PLoS pathogens · 2021Article
- Cell Wall Proteome Profiling of aMicroorganisms · 2021Article
- The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.FEMS microbiology reviews · 2021Review
- The Anti-Biofilm Efficacy of Caffeic Acid Phenethyl Ester (CAPE)Frontiers in cellular and infection microbiology · 2021Article
- Quantification and Pathogenicity of Candida albicans in Denture-Wearing and Nondenture-Wearing Elderly.European journal of dentistry · 2020Article
- Candida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challenges.Mycopathologia · 2020Review
- Global Secretome Characterization of the Pathogenic YeastJournal of proteome research · 2020Article
- Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ywp1 is a prominent glycosylphosphatidylinositol (GPI)-anchored glycoprotein of the cell wall of Candida albicans; it is present in the yeast form of this opportunistic fungal pathogen but absent from filamentous forms and chlamydospores. Yeast cells that lack Ywp1 are more adhesive and form thicker biofilms, implying an antiadhesive activity for Ywp1, with a possible role in yeast dispersal. The antiadhesive effect of Ywp1 is transplantable from yeast to hyphae, as hyphae that are forced to express YWP1 lose adhesion in an in vitro assay. Deletion of the GPI anchor results in loss of Ywp1 to the surrounding medium and reduction of the antiadhesive effect, implying an importance of time-dependent residency in the cell wall. Anchor-negative versions of Ywp1 possessing or lacking a C-terminal green fluorescent protein (GFP) tag were created in C. albicans and harvested from culture supernatants; in addition to serving as quantifiable markers for Ywp1 secretion, they revealed that the cleaved 11-kDa propeptide of Ywp1 remains strongly but noncovalently associated with the Ywp1 core. This association is resistant to highly acidic and basic solutions, 8 M urea, and 1% SDS (below 45°C). Above 50°C, SDS dissociates the isolated complex, but even higher temperatures are required to dissociate the propeptide from native Ywp1 that is anchored in a cell wall. This property has permitted detection, for the first time, of orthologs of Ywp1 in other members of the Candida clade. The cleaved propeptide, which carries the sole N-glycan of Ywp1, must participate in the antiadhesive effect of Ywp1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.