ArticleMolecular human reproduction2012
Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss.
Article in Molecular human reproduction, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- NSUN2-Mediated mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Association between Histidine-Rich Glycoprotein rs10770 Genotype and Recurrent Miscarriage in Iranian Women.BioMed research international · 2024Article
- miR604A>G gene polymorphism is associated with recurrent pregnancy loss in Turkish women.Revista da Associacao Medica Brasileira (1992) · 2023Article
- IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies.International journal of molecular sciences · 2022Review
- Overexpression of long non-coding RNA NEAT1 enhances cell viability and inhibits apoptosis in recurrent spontaneous abortion by targeting the miR-125b/BCL-2 axis.Experimental and therapeutic medicine · 2022Article
- Multiomics Studies Investigating Recurrent Pregnancy Loss: An Effective Tool for Mechanism Exploration.Frontiers in immunology · 2022Review
- Circular RNA FOXP1 relieves trophoblastic cell dysfunction in recurrent pregnancy loss via the miR-143-3p/S100A11 cascade.Bioengineered · 2021Article
- The precise determination of the window of implantation significantly improves ART outcomes.Scientific reports · 2021Article
- Genetic Polymorphisms inInternational journal of molecular sciences · 2021Article
- Whole Genome Sequencing Reveals the Effects of Recent Artificial Selection on Litter Size of Bamei Mutton Sheep.Animals : an open access journal from MDPI · 2021Article
- A systematic review to guide future efforts in the determination of genetic causes of pregnancy loss.Frontiers in reproductive health · 2021Article
- DNA Methylation and Recurrent Pregnancy Loss: A Mysterious Compass?Frontiers in immunology · 2021Review
- Evaluation of 1,25(OH)2D3 Effects on FOXP3, ROR-γt, GITR, and CTLA-4 Gene Expression in the PBMCs of Vitamin D-Deficient Women with Unexplained Recurrent Pregnancy Loss (URPL).Iranian biomedical journal · 2020Article
- NLRP3 Inflammasome and Its Critical Role in Gynecological Disorders and Obstetrical Complications.Frontiers in immunology · 2020Review
- MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.International journal of biological sciences · 2020Article
- Endometrial Immune Dysfunction in Recurrent Pregnancy Loss.International journal of molecular sciences · 2019Review
- The role of FAS, FAS-L, BAX, and BCL-2 gene polymorphisms in determining susceptibility to unexplained recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2019Article
- KDM4B: A Nail for Every Hammer?Genes · 2019Review
- Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism.EBioMedicine · 2019Article
- Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy loss.EBioMedicine · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Recurrent pregnancy loss (RPL) occurs in ∼5% of women. However, the etiology is still poorly understood. Defects in decidualization of the endometrium during early pregnancy contribute to several pregnancy complications, such as pre-eclampsia and intrauterine growth restriction (IUGR), and are believed to be important in the pathogenesis of idiopathic RPL. We performed microarray analysis to identify gene expression alterations in the deciduas of idiopathic RPL patients. Control patients had one antecedent term delivery, but were undergoing dilation and curettage for current aneuploid miscarriage. Gene expression differences were evaluated using both pathway and gene ontology (GO) analysis. Selected genes were validated using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A total of 155 genes were found to be significantly dysregulated in the deciduas of RPL patients (>2-fold change, P < 0.05), with 22 genes up-regulated and 133 genes down-regulated. GO analysis linked a large percentage of genes to discrete biological functions, including immune response (23%), cell signaling (18%) and cell invasion (17.1%), and pathway analysis revealed consistent changes in both the interleukin 1 (IL-1) and IL-8 pathways. All genes in the IL-8 pathway were up-regulated while genes in the IL-1 pathway were down-regulated. Although both pathways can promote inflammation, IL-1 pathway activity is important for normal implantation. Additionally, genes known to be critical for degradation of the extracellular matrix, including matrix metalloproteinase 26 and serine peptidase inhibitor Kazal-type 1, were also highly up-regulated. In this first microarray approach to decidual gene expression in RPL patients, our data suggest that dysregulation of genes associated with cell invasion and immunity may contribute significantly to idiopathic recurrent miscarriage.
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