ReviewIslets
Mathematical models of pancreatic islet size distributions.
Review in Islets. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression.Nature communications · 2026Article
- Volume and functional changes of remnant pancreas after different types of pancreatectomy: Exploring the regenerative potential.Scientific reports · 2026Article
- Article
- Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression.bioRxiv : the preprint server for biology · 2025Article
- Assessing the Effect of Incretin Hormones and Other Insulin Secretagogues on Pancreatic Beta-Cell Function: Review on Mathematical Modelling Approaches.Biomedicines · 2022Review
- Intercellular Communication in the Islet of Langerhans in Health and Disease.Comprehensive Physiology · 2021Article
- Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease.The Journal of pathology · 2021Article
- CD8Frontiers in immunology · 2021Article
- Tracing the cellular basis of islet specification in mouse pancreas.Nature communications · 2020Article
- A Novel Pancreatic Imaging Window for Stabilized LongitudinalDiabetes & metabolism journal · 2020Article
- Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet.Molecular metabolism · 2018Article
- Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes.Scientific reports · 2017Article
- The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation.Development (Cambridge, England) · 2017Article
- Stereological analyses of the whole human pancreas.Scientific reports · 2016Article
- Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells.Journal of diabetes research · 2016Article
- Development, growth and maintenance of β-cell mass: models are also part of the story.Molecular aspects of medicine · 2015Review
- Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass.The Journal of biological chemistry · 2015Article
- Dynamics of glucose and insulin concentration connected to the β-cell cycle: model development and analysis.Theoretical biology & medical modelling · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The islets of Langerhans, ranging in size from clusters of a few cells to several thousand cells, are scattered near large blood vessels. While the β-cell mass in mammals is proportional to body weight, the size ranges of islets are similar between species with different body sizes, possibly reflecting an optimal functional size. The large range of islet sizes suggests a stochastic developmental process. It is not fully understood how islets develop to reach such size distributions, and how their sizes change under certain physiological and pathological conditions such as development, pregnancy, aging, obesity, and diabetes. The lack of a high-resolution in vivo imaging technique for pancreatic islets implies that the only data available to elucidate the dynamics of islet development are cross-sectional quantifications of islet size distributions. In this review, we infer biological processes affecting islet morphology in the large by examining changes of islet size distributions. Neonatal islet formation and growth is shown as a particular example of developing a mathematical model of islet size distribution. Application of this modeling to elucidate islet changes under other conditions is also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.