ArticleApplied and environmental microbiology2012
Bactericidal antibiotics do not appear to cause oxidative stress in Listeria monocytogenes.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Transcriptome Sequencing Reveals Distinct Stress Response of Listeria monocytogenes 6179 During Logarithmic and Stationary Growth Phases.MicrobiologyOpen · 2025Article
- Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS.Nature communications · 2024Article
- An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis.Nature communications · 2023Article
- Article
- Antimicrobial and antioxidant potential of different solvent extracts of the medicinal plant Geum urbanum L.Chemistry Central journal · 2017Article
- Sublethal Concentrations of Antibiotics Cause Shift to Anaerobic Metabolism in Listeria monocytogenes and Induce Phenotypes Linked to Antibiotic Tolerance.Frontiers in microbiology · 2016Article
- Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus.Bioscience reports · 2015Article
- Regulation of oxidative stress resistance in Campylobacter jejuni, a microaerophilic foodborne pathogen.Frontiers in microbiology · 2015Review
- Article
- Survival of bactericidal antibiotic treatment by a persister subpopulation of Listeria monocytogenes.Applied and environmental microbiology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress can be an important contributor to the lethal effect of bactericidal antibiotics in some bacteria, such as Escherichia coli and Staphylococcus aureus. Thus, despite the different target-specific actions of bactericidal antibiotics, they have a common mechanism leading to bacterial self-destruction by internal production of hydroxyl radicals. The purpose of the present study was to determine if a similar mechanism is involved in antibiotic killing of the infectious human pathogen, Listeria monocytogenes. We treated wild-type L. monocytogenes and oxidative stress mutants (Δsod and Δfri) with three different bactericidal antibiotics and found no difference in killing kinetics. In contrast, wild-type E. coli and an oxidative stress mutant (ΔsodA ΔsodB) differed significantly in their sensitivity to bactericidal antibiotics. We conclude that bactericidal antibiotics did not appear to cause oxidative stress in L. monocytogenes and propose that this is caused by its noncyclic tricarboxylic acid (TCA) pathway. Hence, in this noncyclic metabolism, there is a decoupling between the antibiotic-mediated cellular requirement for NADH and the induction of TCA enzyme activity, which is believed to mediate the oxidative stress reaction.
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