ArticleJournal of immunology (Baltimore, Md. : 1950)2012
B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Experimental inoculation of CD11cAccess microbiology · 2020Article
- Oral Prion Neuroinvasion Occurs Independently of PrPJournal of virology · 2018Article
- How do PrPPathogens (Basel, Switzerland) · 2017Review
- Article
- Oral Prion Disease Pathogenesis Is Impeded in the Specific Absence of CXCR5-Expressing Dendritic Cells.Journal of virology · 2017Article
- Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility.PLoS pathogens · 2016Article
- The Gut-Associated Lymphoid Tissues in the Small Intestine, Not the Large Intestine, Play a Major Role in Oral Prion Disease Pathogenesis.Journal of virology · 2015Article
- Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays.Journal of veterinary science · 2015Article
- Hypertrophy of infected Peyer's patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress.Mucosal immunology · 2014Article
- Identification of co-expressed gene signatures in mouse B1, marginal zone and B2 B-cell populations.Immunology · 2014Article
- Accumulation profiles of PrP(Sc) in hemal nodes of naturally and experimentally scrapie-infected sheep.BMC veterinary research · 2013Article
- Immunization with recombinant prion protein leads to partial protection in a murine model of TSEs through a novel mechanism.PloS one · 2013Article
- Prion disease and the innate immune system.Viruses · 2012Review
- Follicular dendritic cells in health and disease.Frontiers in immunology · 2012Article
- Article
- Animal prion diseases: A review of intraspecies transmission.Open veterinary journalReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Many prion diseases are peripherally acquired (e.g., orally or via lesions to skin or mucous membranes). After peripheral exposure, prions replicate first upon follicular dendritic cells (FDC) in the draining lymphoid tissue before infecting the brain. However, after replication upon FDC within the draining lymphoid tissue, prions are subsequently propagated to most nondraining secondary lymphoid organs (SLO), including the spleen, by a previously underdetermined mechanism. The germinal centers in which FDC are situated produce a population of B cells that can recirculate between SLO. Therefore, we reasoned that B cells were ideal candidates by which prion dissemination between SLO may occur. Sphingosine 1-phosphate receptor (S1PR)1 stimulation controls the egress of T and B cells from SLO. S1PR1 signaling blockade sequesters lymphocytes within SLO, resulting in lymphopenia in the blood and lymph. We show that, in mice treated with the S1PR modulator FTY720 or with S1PR1 deficiency restricted to B cells, the dissemination of prions from the draining lymph node to nondraining SLO is blocked. These data suggest that B cells interacting with and acquiring surface proteins from FDC and recirculating between SLO via the blood and lymph mediate the initial propagation of prions from the draining lymphoid tissue to peripheral tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.