ArticleToxicologic pathology2012
Magnetic resonance histology of age-related nephropathy in the Sprague Dawley rat.
Article in Toxicologic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
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- Super-Resolution Ultrasound Imaging Provides Quantification of the Renal Cortical and Medullary Vasculature in Obese Zucker Rats: A Pilot Study.Diagnostics (Basel, Switzerland) · 2022Article
- An in silico validation framework for quantitative DCE-MRI techniques based on a dynamic digital phantom.Medical image analysis · 2021Article
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- Micro computed tomography with and without contrast enhancement for the characterization of microcarriers in dry and wet state.Scientific reports · 2021Article
- High-resolution MRI of kidney microstructures at 7.05 T with an endo-colonic Wireless Amplified NMR detector.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling.Scientific reports · 2018Article
- Image-based gradient non-linearity characterization to determine higher-order spherical harmonic coefficients for improved spatial position accuracy in magnetic resonance imaging.Magnetic resonance imaging · 2017Article
- Robust nanobubble and nanodroplet segmentation in atomic force microscope images using the spherical Hough transform.Beilstein journal of nanotechnology · 2017Article
- MRI tools for assessment of microstructure and nephron function of the kidney.American journal of physiology. Renal physiology · 2016Review
- Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping.NeuroImage · 2016Article
- Susceptibility tensor imaging of the kidney and its microstructural underpinnings.Magnetic resonance in medicine · 2015Article
- Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology.Frontiers in pharmacology · 2015Review
- Live nephron imaging by MRI.American journal of physiology. Renal physiology · 2014Article
- Four-dimensional MRI of renal function in the developing mouse.NMR in biomedicine · 2014Article
- Why and how we determine nephron number.Pediatric nephrology (Berlin, Germany) · 2014Review
- Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice.NMR in biomedicine · 2013Article
- MRI-detectable nanoparticles: the potential role in the diagnosis of and therapy for chronic kidney disease.Advances in chronic kidney disease · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Magnetic resonance histology (MRH) has become a valuable tool in evaluating drug-induced toxicity in preclinical models. However, its application in renal injury has been limited. This study tested the hypothesis that MRH could detect image-based biomarkers of chronic disease, inflammation, or age-related degeneration in the kidney, laying the foundation for more extensive use in evaluating drug toxicity. We examined the entire intact kidney in a spontaneous model of chronic progressive nephropathy. Kidneys from male Sprague Dawley rats were imaged at 8 weeks (n = 4) and 52 weeks (n =4) on a 9.4 T system dedicated to MR microscopy. Several potential contrast mechanisms were explored to optimize the scanning protocols. Full coverage of the entire kidney was achieved with isotropic spatial resolution at 31 microns (voxel volume = 30 pL) using a gradient recalled echo sequence. Isotropic spatial resolution of 15 microns (voxel volume < 4 pL) was achieved in a biopsy core specimen. Qualitative age-related structural changes, such as renal cortical microvasculature, tubular dilation, interstitial fibrosis, and glomerular architecture, were apparent. The nondestructive 3D images allowed measurement of quantitative differences of kidney volume, pelvis volume, main vessel volume, glomerular size, as well as thickness of the cortex, outer medulla, and inner medulla.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.