ArticleNature cell biology2012
Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila.
Article in Nature cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Ectoderm tensile stress controls mesoderm internalization during embryo gastrulation.Nature communications · 2026Article
- EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster.Developmental cell · 2025Article
- Spatio-Temporal Regulation of Notch Activation in Asymmetrically Dividing Sensory Organ Precursor Cells inCells · 2024Review
- EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues.bioRxiv : the preprint server for biology · 2023Article
- Molecular and functional characterization of the Drosophila melanogaster conserved smORFome.Cell reports · 2023Article
- Crumbs complex-directed apical membrane dynamics in epithelial cell ingression.The Journal of cell biology · 2022Article
- Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature.Development (Cambridge, England) · 2021Article
- Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized.The Journal of cell biology · 2020Article
- Collective Migrations ofGenetics · 2020Review
- The Physical Mechanisms ofGenetics · 2020Article
- Setting up for gastrulation: D. melanogaster.Current topics in developmental biology · 2020Review
- Notch-mediated inhibition of neurogenesis is required for zebrafish spinal cord morphogenesis.Scientific reports · 2019Article
- Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem Cell Differentiation in Drosophila.Stem cell reports · 2019Article
- Insight into Notch Signaling Steps That InvolveGenetics · 2018Article
- Quantitative Control of GPCR Organization and Signaling by Endocytosis in Epithelial Morphogenesis.Current biology : CB · 2018Article
- Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila.Nature communications · 2017Article
- Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms.The Journal of cell biology · 2017Article
- Stardust, the Janus-faced partner of Crumbs.The Journal of cell biology · 2017Article
- From morphogen to morphogenesis and back.Nature · 2017Review
- Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly.The Journal of cell biology · 2016Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how epithelial polarity is established and regulated during tissue morphogenesis is a major issue. Here, we identify a regulatory mechanism important for mesoderm invagination, germ-band extension and transepithelial migration in the Drosophila melanogaster embryo. This mechanism involves the inhibition of the conserved E3 ubiquitin ligase Neuralized by proteins of the Bearded family. First, Bearded mutant embryos exhibited a loss of epithelial polarity associated with an early loss of the apical domain. Bearded regulated epithelial polarity by antagonizing neuralized. Second, repression of Bearded gene expression by Snail was required for the Snail-dependent disassembly of adherens junctions in the mesoderm. Third, neuralized was strictly required to promote the downregulation of the apical domain in the midgut epithelium and to facilitate the transepithelial migration of primordial germ cells across this epithelium. This function of Neuralized was independent of its known role in Notch signalling. Thus, Neuralized has two distinct functions in epithelial cell polarity and Notch signalling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.