ArticleDevelopmental and comparative immunology2012
Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium.
Article in Developmental and comparative immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Deciphering the M-cell niche: insights from mouse models on how microfold cells "know" where they are needed.Frontiers in immunology · 2024Review
- Notch inhibitors induce diarrhea, hypercrinia and secretory cell metaplasia in the human colon.EXCLI journal · 2021Article
- Article
- The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases.Frontiers in immunology · 2019Review
- M Cells: Intelligent Engineering of Mucosal Immune Surveillance.Frontiers in immunology · 2019Review
- Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.The Journal of experimental medicine · 2018Article
- Unusual suspects: dancing with stromal cells.Nature immunology · 2017Article
- Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines.Experimental & molecular medicine · 2014Review
- Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond.Frontiers in immunology · 2014Review
- Article
- Freeze-dried targeted mannosylated selenium-loaded nanoliposomes: development and evaluation.AAPS PharmSciTech · 2013Article
- Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium.Mucosal immunology · 2013Review
- Distinct TCR signaling pathways drive proliferation and cytokine production in T cells.Nature immunology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mucosal epithelium M cells are dispersed across Peyer's patch follicle associated epithelium (PPFAE) with minimal clustering. Since Notch signaling can influence patterning in epithelia, we examined its influence on PPFAE M cell distribution. Conditional deletion of Notch1 in intestinal epithelium increased PPFAE M cells and also increased M cell clustering, implying a role for Notch in both M cell numbers and lateral inhibition. By contrast, conditional deletion of the ligand Jagged1 also increased M cell clustering, but with a paradoxical decrease in M cell density. In vitro, inhibition of Notch signaling reduced expression of an M cell associated gene CD137, consistent with cis-promoting effects on M cell development. Thus, Jagged1 may have a cis-promoting role in committed M cells, but a trans-inhibitory effect on neighboring cells. In sum, Jagged1-Notch signaling may edit the pattern of M cells across the PPFAE, which may help optimize mucosal immune surveillance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.