ReviewCurrent opinion in microbiology2012
Antigenic variation and the generation of diversity in malaria parasites.
Review in Current opinion in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Seasonal Climate Drivers and Immunohematological Profiles of Malaria in Rohingya Refugee Camps, Bangladesh: A 4-Year Repeated Cross-Sectional Study.Journal of parasitology research · 2026Article
- Exploring Biomarkers for Malaria: Advances in Early Detection and Asymptomatic Diagnosis.Biosensors · 2025Review
- Uncovering the role of Rad51 in homologous recombination-mediated antigenic diversification in the human malaria parasiteFrontiers in molecular biosciences · 2023Article
- Changing of the guard: How the Lyme disease spirochete subverts the host immune response.The Journal of biological chemistry · 2020Review
- Review
- Competition for hosts modulates vast antigenic diversity to generate persistent strain structure in Plasmodium falciparum.PLoS biology · 2019Article
- Multiscale Immune Selection and the Transmission-Diversity Feedback in Antigenically Diverse Pathogen Systems.The American naturalist · 2018Article
- CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum.Journal of visualized experiments : JoVE · 2018Article
- RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics.PLoS genetics · 2018Article
- A bite to fight: front-line innate immune defenses against malaria parasites.Pathogens and global health · 2018Review
- Extreme mutation bias and high AT content in Plasmodium falciparum.Nucleic acids research · 2017Article
- Genomic resources for a unique, low-virulence Babesia taxon from China.Parasites & vectors · 2016Article
- Malaria vaccines and human immune responses.Current opinion in microbiology · 2016Review
- Malaria modeling: In vitro stem cells vs in vivo models.World journal of stem cells · 2016Review
- Transmission-blocking strategies: the roadmap from laboratory bench to the community.Malaria journal · 2016Review
- The Plasmodium PHIST and RESA-Like Protein Families of Human and Rodent Malaria Parasites.PloS one · 2016Article
- Recombinant modified vaccinia virus Ankara-based malaria vaccines.Expert review of vaccines · 2016Review
- Comparative genomic analyses of freshly isolated Giardia intestinalis assemblage A isolates.BMC genomics · 2015Article
- Inositol phosphate pathway controls transcription of telomeric expression sites in trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Investigations into the genetic basis underlying antigenic variation in malaria parasites have primarily described transcriptional regulation of the large, multi-copy gene families that encode red cell surface antigens. In particular, extensive alterations to chromatin structure and subnuclear localization have been shown to play key roles in mutually exclusive expression, gene silencing and activation, and epigenetic memory. However the mechanisms responsible for the generation of sequence diversity within these gene families, a characteristic that is equally important for a parasite's ability to avoid the host's immune response, remains poorly understood in malaria. Recent work in model organisms suggests that the mechanisms controlling gene activation and silencing might also contribute to preferential recombination between antigen encoding genes, thus linking these two key processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.