ReviewMolecular aspects of medicine2012
Nutritional modulation of age-related macular degeneration.
Review in Molecular aspects of medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dietary fatty acid intake, plasma fatty acid levels, and the risk of age-related macular degeneration (AMD): a dose-response meta-analysis of prospective cohort studies.European journal of nutrition · 2021Pooled it
- The effect of lutein supplementation on blood plasma levels of complement factor D, C5a and C3d.PloS one · 2013Trial
- Article
- Association of Corneal Biomechanical Properties with Fingertip-Measured Advanced Glycation End Products and Carotenoids in Glaucoma Patients.Journal of clinical medicine · 2026Article
- Choroidal Control Technology: New Horizons in Maculopathy and Presbyopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Glycative stress as a cause of macular degeneration.Progress in retinal and eye research · 2024Review
- Association between dietary consumption of fatty acids and age-related macular degeneration in the National Health and Nutrition Examination Survey.Scientific reports · 2024Article
- Retinal Microvasculature and Neural Changes and Dietary Patterns in an Older Population in Southern Italy.International journal of environmental research and public health · 2023Article
- Article
- Inside out: Relations between the microbiome, nutrition, and eye health.Experimental eye research · 2022Review
- Article
- Review of Evidence for the Usage of Antioxidants for Eye Aging.BioMed research international · 2022Review
- Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy.Genes & diseases · 2022Review
- Article
- Short-Term High Fructose Intake Impairs Diurnal Oscillations in the Murine Cornea.Investigative ophthalmology & visual science · 2021Article
- Glyoxalase System as a Therapeutic Target against Diabetic Retinopathy.Antioxidants (Basel, Switzerland) · 2020Review
- Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases.Nutrients · 2020Review
- A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration.Free radical biology & medicine · 2020Article
- Article
- Nutrition and Eye Health.Nutrients · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in excess of $340 billion US (American-Health-Assistance-Foundation, 2012). The majority of AMD patients in the United States are not eligible for clinical treatments (Biarnes et al., 2011; Klein et al., 2011). Preventive interventions through dietary modulation are attractive strategies because many studies suggest a benefit of micro- and macronutrients with respect to AMD, as well as other age-related debilities, and with few, if any, adverse effects (Chiu, 2011). Preservation of vision would enhance quality of life for millions of elderly people, and alleviate the personal and public health financial burden of AMD (Frick et al., 2007; Wood et al., 2011). Observational studies indicate that maintaining adequate levels of omega-3 fatty acids (i.e. with 2 servings/week of fish) or a low glycemic index diet may be particularly beneficial for early AMD and that higher levels of carotenoids may be protective, most probably, against neovascular AMD. Intervention trials are needed to better understand the full effect of these nutrients and/or combinations of nutrients on retinal health. Analyses that describe effects of a nutrient on onset and/or progress of AMD are valuable because they indicate the value of a nutrient to arrest AMD at the early stages. This comprehensive summary provides essential information about the value of nutrients with regard to diminishing risk for onset or progress of AMD and can serve as a guide until data from ongoing intervention trials are available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.