ArticleCurrent biology : CB2012
Ascaroside signaling is widely conserved among nematodes.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed, 226 citations in OpenAlex.
- Redox Regulation of Plant-Root-Knot Nematode Interactions: From ROS-Mediated Immunity to Sustainable Resistance.Antioxidants (Basel, Switzerland) · 2026Review
- Synergy of Ascr#11 and Improved Aeration Drives Enhanced Yield and Fitness of Entomopathogenic Nematodes.Life (Basel, Switzerland) · 2026Article
- Maternal age modulates progeny social behavior via a small RNA-neuropeptide axis.bioRxiv : the preprint server for biology · 2026Article
- Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male.Nature communications · 2026Article
- A Cold Stress-Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cyclohexyl acetate functions like a volatile sex pheromone mimic in Caenorhabditis nematodes.BMC biology · 2026Article
- O-acyltransferase genes involved in the production of volatile sex pheromones inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genomic parallelism defines repeated evolution of an inducible offense.Science advances · 2025Article
- Biosynthesis of modular signaling molecules requires functional diversification of carboxylesterases in Pristionchus pacificus.Communications biology · 2025Article
- Nematode Pheromones as Key Mediators of Behavior, Development, and Ecological Interactions.Biomolecules · 2025Review
- Comparative Metabolomics Identifies the Roles of Acyl-CoA Oxidases in the Biosynthesis of Ascarosides and a Complex Family of SecretedACS chemical biology · 2025Article
- Metabolomic and functional analyses of small molecules secreted by intestinal nematodes in the activation of epithelial tuft cells.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Genomic and Transcriptomic Analyses Revealed DdSTE2 Play a Role in Constricting Ring Formation in the Nematode-Trapping FungiMicroorganisms · 2024Article
- Meloidogyne incognita genes involved in the repellent behavior in response to ascr#9.Scientific reports · 2024Article
- The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors.Nature microbiology · 2024Article
- Genetic regulators of a resource polyphenism interact to couple predatory morphology and behaviour.Proceedings. Biological sciences · 2024Article
- Natural genetic variation in the pheromone production ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Repurposing degradation pathways for modular metabolite biosynthesis in nematodes.Nature chemical biology · 2023Review
- Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in Caenorhabditis elegans.Genetics · 2023Article
- Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023Review
44 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundNematodes are among the most successful animals on earth and include important human pathogens, yet little is known about nematode pheromone systems. A group of small molecules called ascarosides has been found to mediate mate finding, aggregation, and developmental diapause in Caenorhabditis elegans, but it is unknown whether ascaroside signaling exists outside of the genus Caenorhabditis.
resultsTo determine whether ascarosides are used as signaling molecules by other nematode species, we performed a mass spectrometry-based screen for ascarosides in secretions from a variety of both free-living and parasitic (plant, insect, and animal) nematodes. We found that most of the species analyzed, including nematodes from several different clades, produce species-specific ascaroside mixtures. In some cases, ascaroside biosynthesis patterns appear to correlate with phylogeny, whereas in other cases, biosynthesis seems to correlate with lifestyle and ecological niche. We further show that ascarosides mediate distinct nematode behaviors, such as retention, avoidance, and long-range attraction, and that different nematode species respond to distinct, but overlapping, sets of ascarosides.
conclusionsOur findings indicate that nematodes utilize a conserved family of signaling molecules despite having evolved to occupy diverse ecologies. Their structural features and level of conservation are evocative of bacterial quorum sensing, where acyl homoserine lactones (AHLs) are both produced and sensed by many species of gram-negative bacteria. The identification of species-specific ascaroside profiles may enable pheromone-based approaches to interfere with reproduction and survival of parasitic nematodes, which are responsible for significant agricultural losses and many human diseases worldwide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.