Evidence map›Paper›PMID 22503302›Full record

Trial reportOphthalmology2012

Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians.

William G Christen, Robert J Glynn, Howard D Sesso, Tobias Kurth, Jean Macfadyen, Vadim Bubes, Julie E Buring, Joann E Manson, J Michael Gaziano

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00270647 (Physicians' Health Study II), which is not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00270647 nacompletednot on this map

Physicians' Health Study II: Trial of Vitamins in the Chemoprevention of Cancer, CVD, and Eye Disease

TypeinterventionalSponsorBrigham and Women's HospitalRan1997 to 2011Enrolled14,641ConditionsCancer, Prostate Cancer, Colorectal Cancer, Cardiovascular DiseaseArmsVitamin E, Vitamin C, Multivitamin, Beta-carotene
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  12. Oxidative Stress and Microglial Response in Retinitis Pigmentosa.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

William G ChristenDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. wchristen@rics.bwh.harvard.edu
Robert J Glynn
Howard D Sesso
Tobias Kurth
Jean Macfadyen
Vadim Bubes
Julie E Buring
Joann E Manson
J Michael Gaziano
Brigham and Women's Hospital · USHarvard University · USVA Boston Healthcare System · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Physicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7M
RANDOMIZED TRIAL OF ASPIRIN AND MORTALITYR01CA040360 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 2002
$775k
TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'SR01HL034595 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 1991
–
NCI NIH HHS CA 34944NCI NIH HHS CA 40360NCI NIH HHS CA 97193NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA097193NHLBI NIH HHS HL 26490NHLBI NIH HHS HL 34595NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

purposeTo test whether supplementation with alternate-day vitamin E or daily vitamin C affects the incidence of the diagnosis of age-related macular degeneration (AMD) in a large-scale randomized trial of male physicians.

designRandomized, double-masked, placebo-controlled trial.

participantsWe included 14 236 apparently healthy United States male physicians aged ≥50 years who did not report a diagnosis of AMD at baseline.

methodsParticipants were randomly assigned to receive 400 international units (IU) of vitamin E or placebo on alternate days, and 500 mg of vitamin C or placebo daily. Participants reported new diagnoses of AMD on annual questionnaires and medical record data were collected to confirm the reports.

main outcome measuresIncident diagnosis of AMD responsible for a reduction in best-corrected visual acuity to ≤20/30.

resultsAfter 8 years of treatment and follow-up, a total of 193 incident cases of visually significant AMD were documented. There were 96 cases in the vitamin E group and 97 in the placebo group (hazard ratio [HR], 1.03; 95% confidence interval [CI], 0.78-1.37). For vitamin C, there were 97 cases in the active group and 96 in the placebo group (HR, 0.99; 95% CI, 0.75-1.31).

conclusionsIn a large-scale, randomized trial of United States male physicians, alternate-day use of 400 IU of vitamin E and/or daily use of 500 mg of vitamin C for 8 years had no appreciable beneficial or harmful effect on risk of incident diagnosis of AMD.

Indexed as

AgedAscorbic AcidDietary SupplementsDouble-Blind MethodDrug CombinationsHumansIncidenceMacular DegenerationMaleMiddle AgedPhysiciansRisk FactorsSurveys and QuestionnairesUnited StatesVisual AcuityVitamin EAscorbic AcidDrug CombinationsVitamin EVitamins

Identifiers

PMID22503302
PMCPMC3535014
OpenAlexW2004904863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.