ArticleAutonomic neuroscience : basic & clinical2012
Activated cranial cervical cord neurons affect left ventricular infarct size and the potential for sudden cardiac death.
Article in Autonomic neuroscience : basic & clinical, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Cardiac sympathectomy and spinal cord stimulation attenuate reflex-mediated norepinephrine release during ischemia preventing ventricular fibrillation.JCI insight · 2019Article
- Thoracic spinal cord neuromodulation obtunds dorsal root ganglion afferent neuronal transduction of the ischemic ventricle.American journal of physiology. Heart and circulatory physiology · 2019Article
- Involvement of sphingosine-1-phosphate receptors 2/3 in IR-induced sudden cardiac death.Heart and vessels · 2019Article
- Calming the Nervous Heart: Autonomic Therapies in Heart Failure.Cardiac failure review · 2018Review
- Defining the neural fulcrum for chronic vagus nerve stimulation: implications for integrated cardiac control.The Journal of physiology · 2017Article
- Bioelectronic block of paravertebral sympathetic nerves mitigates post-myocardial infarction ventricular arrhythmias.Heart rhythm · 2017Article
- Vagal stimulation targets select populations of intrinsic cardiac neurons to control neurally induced atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2016Article
- Translational neurocardiology: preclinical models and cardioneural integrative aspects.The Journal of physiology · 2016Review
- Vagus nerve stimulation mitigates intrinsic cardiac neuronal and adverse myocyte remodeling postmyocardial infarction.American journal of physiology. Heart and circulatory physiology · 2015Article
- Autonomic Regulation Therapy in Heart Failure.Current heart failure reports · 2015Review
- Cardiac innervation and sudden cardiac death.Circulation research · 2015Review
- Neural mechanisms of cardioprotection.Physiology (Bethesda, Md.) · 2014Review
- Network interactions within the canine intrinsic cardiac nervous system: implications for reflex control of regional cardiac function.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
To evaluate whether cervical spinal neurons can influence cardiac indices and myocyte viability in the acutely ischemic heart, the hearts of anesthetized rabbits subjected to 30 min of LAD coronary arterial occlusion (CAO) were studied 3h after reperfusion. Control animals were compared to those exposed to pre-emptive high cervical cord stimulation (SCS; the dorsal aspect of the C1-C2 spinal cord was stimulated electrically at 50 Hz; 0.2 ms; 90% of motor threshold, starting 15 min prior to and continuing throughout CAO). Four groups of animals were so tested: 1) neuroaxis intact; 2) prior cervical vagotomy; 3) prior transection of the dorsal spinal columns at C6; and 4) following pharmacological treatment [muscarinic (atropine) or adrenergic (atenolol, prazosin or yohimbine) receptor blockade]. Infarct size (IS) was measured by tetrazolium, expressed as percentage of risk zone. C1-C2 SCS reduced acute ischemia induced IS by 43%, without changing the incidence of sudden cardiac death (SCD). While SCS-induced reduction in IS was unaffected by vagotomy, it was no longer evident following transection of C6 dorsal columns or atropinization. Beta-adrenoceptor blockade eliminated ischemia induced SCD, while alpha-receptor blockade doubled its incidence. During SCS, myocardial ischemia induced SCD was eliminated following vagotomy while remaining unaffected by atropinization. These data indicate that, in contrast to thoracic spinal neurons, i) cranial cervical spinal neurons affect both adrenergic and cholinergic motor outflows to the heart such that ii) their activation modifies ventricular infarct size and lethal arrhythmogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.