ReviewJournal of electron microscopy technique1990
Morphology of mammalian sperm membranes during differentiation, maturation, and capacitation.
Review in Journal of electron microscopy technique, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Field Emission Scanning Electron Microscopy (FE-SEM) as an Approach for Membrane Surface Mapping in Cell Biology.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Quantification and Topographical Distribution of Terminal and Linked Fucose Residues in Human Spermatozoa by Using Field Emission Scanning Electron Microscopy (FE-SEM).International journal of molecular sciences · 2021Article
- Advancing Semen Evaluation Using Lipidomics.Frontiers in veterinary science · 2021Review
- Lectin spatial immunolocalization duringAnimal reproduction · 2020Article
- A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Comprehensive profiling of accessible surface glycans of mammalian sperm using a lectin microarray.Clinical proteomics · 2014Article
- Cyclic 3',5'-AMP causes ADAM1/ADAM2 to rapidly diffuse within the plasma membrane of guinea pig sperm.Biology of reproduction · 2008Article
- pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution.The Journal of physiology · 2007Article
- The carbohydrate structure of DEFB126, the major component of the cynomolgus Macaque sperm plasma membrane glycocalyx.The Journal of membrane biology · 2005Article
- Ubiquitin signals in the developing acrosome during spermatogenesis of rat testis: an immunoelectron microscopic study.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2004Article
- Electron microscopic study of human sperm membrane isolation.Journal of assisted reproduction and genetics · 1994Article
- Sperm subpopulations in avian species: a comparative study between the rooster (Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The mammalian spermatozoon is a highly polarized cell whose surface membrane can be divided into five functionally, structurally, and biochemically distinct domains. These domains are formed during spermatogenesis, continue to be modified during passage through the epididymis, and are further refined in the female reproductive tract. The integrity of these domains appears to be necessary for the sperm to perform its function--fusion with the egg and subsequent fertilization. The domains can be identified morphologically by their surface contours and texture, the content, distribution, and organization of intramembranous particles after freeze-fracture, and by the density of surface and cytoplasmic electron-dense coatings in thin sections. By using a variety of labels that stain carbohydrates (lectins), lipids (filipin and polymyxin B), and monoclonal antibodies to specific membrane constituents, the biochemical composition of these contiguous membrane regions has also been partly elucidated. We review here what is known about the structure, composition, and behavior of each membrane domain in the mature sperm and include some information regarding domain formation during spermatogenesis. The sperm is an excellent model system to study the creation and maintenance of cell polarity, granule exocytosis, and fertilization. Hopefully this review will provide impetus for future studies aimed more directly at addressing the relationship of its morphology to its functions.
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Registered trials
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