ReviewImmunological reviews2012
Contribution of Toll-like receptor signaling to germinal center antibody responses.
Review in Immunological reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 70 citations in OpenAlex.
- Cell-Based Assays to Detect Innate Immune Response Modulating Impurities: Application to Biosimilar Insulin.The AAPS journal · 2024Article
- Autophagy Induced by Toll-like Receptor Ligands Regulates Antigen Extraction and Presentation by B Cells.Cells · 2022Article
- E6020, a TLR4 Agonist Adjuvant, Enhances Both Antibody Titers and Isotype Switching in Response to Immunization with Hapten-Protein Antigens and Is Diminished in Mice with TLR4 Signaling Insufficiency.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates.Cell reports. Medicine · 2021Article
- Germinal Centre Shutdown.Frontiers in immunology · 2021Review
- TLR7 Signaling Shapes and Maintains Antibody Diversity Upon Virus-Like Particle Immunization.Frontiers in immunology · 2021Article
- Changes in B Cell Pool of Patients With Multibacillary Leprosy: Diminished Memory B Cell and Enhanced Mature B in Peripheral Blood.Frontiers in immunology · 2021Article
- Mice Plasmacytoid Dendritic Cells Were Activated by Lipopolysaccharides Through Toll-Like Receptor 4/Myeloid Differentiation Factor 2.Frontiers in immunology · 2021Article
- Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity.Immunity · 2020Review
- Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes.ImmunoHorizons · 2019Article
- B cell signaling in context.Nature immunology · 2019Review
- Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR.The EMBO journal · 2019Article
- TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer.Human gene therapy methods · 2019Article
- Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation.Seminars in immunopathology · 2019Review
- Germinal center-derived lymphomas: The darkest side of humoral immunity.Immunological reviews · 2019Review
- Increased influenza-specific antibody avidity in HIV-infected women compared with HIV-infected men on antiretroviral therapy.AIDS (London, England) · 2019Article
- Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention.Frontiers in immunology · 2019Review
- αv Integrins regulate germinal center B cell responses through noncanonical autophagy.The Journal of clinical investigation · 2018Article
- Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.Nature communications · 2018Article
- Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.Oncotarget · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Toll-like receptors (TLRs) have emerged as one of the most important families of innate immune receptors for initiating inflammation and also for promoting adaptive immune responses. Recent studies have examined the ability of TLRs to promote antibody responses, including T-cell-dependent antibody responses. Initial study suggested that TLR stimulation promotes primarily an extrafollicular antibody response, which rapidly produces moderate affinity antibodies made by short-lived plasma cells. Recent studies, however, have shown that TLRs can also enhance the germinal center response, which produces high affinity class-switched antibody made by long-lived plasma cells. TLR stimulation can increase the magnitude of the latter response and also enhance selection for high affinity IgG. This review summarizes recent advances in understanding the roles of TLRs in B cells and also in other cell types for enhancement of antibody responses, with an emphasis on T-cell-dependent and germinal center antibody responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.