ArticleBiophysical journal2012
Lifetime of major histocompatibility complex class-I membrane clusters is controlled by the actin cytoskeleton.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Lipogenesis-driven EGFR palmitoylation enables metastatic immune evasion in triple-negative breast cancer.bioRxiv : the preprint server for biology · 2026Article
- Mechanical regulation of lymphocyte activation and function.Journal of cell science · 2024Review
- Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells.Cellular and molecular life sciences : CMLS · 2022Article
- Article
- Homotypic and heterotypicCurrent research in immunology · 2022Review
- Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation.PLoS pathogens · 2020Article
- Membrane Diffusion Occurs by Continuous-Time Random Walk Sustained by Vesicular Trafficking.Biophysical journal · 2018Article
- Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and IL-15 Receptors in T Cells.Biophysical journal · 2018Article
- Article
- Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins.BMC immunology · 2016Article
- MHC I Expression Regulates Co-clustering and Mobility of Interleukin-2 and -15 Receptors in T Cells.Biophysical journal · 2016Article
- The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling.The Journal of cell biology · 2016Review
- Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse.Frontiers in immunology · 2016Review
- A high fat diet containing saturated but not unsaturated fatty acids enhances T cell receptor clustering on the nanoscale.Prostaglandins, leukotrienes, and essential fatty acids · 2015Article
- Multi-protein assemblies underlie the mesoscale organization of the plasma membrane.Nature communications · 2014Article
- The actin homologue MreB organizes the bacterial cell membrane.Nature communications · 2014Article
- Ultrabright fluorescent mesoporous silica nanoparticles for prescreening of cervical cancer.Nanomedicine : nanotechnology, biology, and medicine · 2013Article
- Dynamic transition states of ErbB1 phosphorylation predicted by spatial stochastic modeling.Biophysical journal · 2013Article
- Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering.Scientific reports · 2013Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lateral heterogeneity of cell membranes has been demonstrated in numerous studies showing anomalous diffusion of membrane proteins; it has been explained by models and experiments suggesting dynamic barriers to free diffusion, that temporarily confine membrane proteins into microscopic patches. This picture, however, comes short of explaining a steady-state patchy distribution of proteins, in face of the transient opening of the barriers. In our previous work we directly imaged persistent clusters of MHC-I, a type I transmembrane protein, and proposed a model of a dynamic equilibrium between proteins newly delivered to the cell surface by vesicle traffic, temporary confinement by dynamic barriers to lateral diffusion, and dispersion of the clusters by diffusion over the dynamic barriers. Our model predicted that the clusters are dynamic, appearing when an exocytic vesicle fuses with the plasma membrane and dispersing with a typical lifetime that depends on lateral diffusion and the dynamics of barriers. In a subsequent work, we showed this to be the case. Here we test another prediction of the model, and show that changing the stability of actin barriers to lateral diffusion changes cluster lifetimes. We also develop a model for the distribution of cluster lifetimes, consistent with the function of barriers to lateral diffusion in maintaining MHC-I clusters.
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