ArticleOrganic and medicinal chemistry letters2012
Pathways of ion-molecular interactions of nucleogenic phenyl cations with the nucleophilic centers of picolines.
Article in Organic and medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
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backgroundThe nuclear-chemical method brought unique opportunity for synthesis of unknown and hardly available organic compounds. Presence of tritium labeling allows one-step preparation of radioactive markers for the investigation of chemical and biological processes.
methodsThe ion-molecular reactions of nucleogenic phenyl cations with 4-picoline have been carried out. The phenyl cations were generated by spontaneous tritium β-decay within the tritium-labeled benzene. Both additions to the nitrogen and substitutions about the aromatic ring were able to be studied simultaneously.
resultsUnusual substitutions on both the α- and β-positions of the ring system have been revealed.
conclusionBy unknown direct phenylation of nitrogen atom tritium-labeled N-phenylpicolinium derivatives, perspective biological markers have been synthesized.
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