ArticleStem cells and development2012
Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells.
Article in Stem cells and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Human trophoblast stem cells restrict human cytomegalovirus replication.Journal of virology · 2024Article
- Autologous stem cell therapy for inherited and acquired retinal disease.Regenerative medicine · 2018Review
- Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review).Molecular medicine reports · 2017Review
- Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.Nature communications · 2016Article
- PRG3 induces Ras-dependent oncogenic cooperation in gliomas.Oncotarget · 2016Article
- Crosstalk between stem cell and cell cycle machineries.Current opinion in cell biology · 2015Review
- Myogenic Precursors from iPS Cells for Skeletal Muscle Cell Replacement Therapy.Journal of clinical medicine · 2015Review
- Prospects for clinical use of reprogrammed cells for autologous treatment of macular degeneration.Fibrogenesis & tissue repair · 2015Article
- Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Plant hormones increase efficiency of reprogramming mouse somatic cells to induced pluripotent stem cells and reduce tumorigenicity.Stem cells and development · 2014Article
- Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proper differentiation and threat of cancer rising from the application of induced pluripotent stem (iPS) cells are major bottlenecks in the field and are thought to be inherently linked to the pluripotent nature of iPS cells. To address this question, we have compared iPS cells to embryonic stem cells (ESCs), the gold standard of ground state pluripotency, in search for proteins that may improve pluripotency of iPS cells. We have found that when reprogramming somatic cells toward pluripotency, 1%-5% of proteins of 5 important cell functions are not set to the correct expression levels compared to ESCs, including mainly cell cycle proteins. We have shown that resetting cyclin A(1) protein expression of early-passage iPS cells closer to the ground state pluripotent state of mouse ESCs improves the pluripotency and reduces the threat of cancer of iPS cells. This work is a proof of principle that reveals that setting expression of certain proteins correctly during reprogramming is essential for achieving ESC-state pluripotency. This finding would be of immediate help to those researchers in different fields of iPS cell work that specializes in cell cycle, apoptosis, cell adhesion, cell signaling, and cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.