ArticleBiologics : targets & therapy2012
Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering.
Article in Biologics : targets & therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Metabolic and Transcriptional Changes across Osteogenic Differentiation of Mesenchymal Stromal Cells.Bioengineering (Basel, Switzerland) · 2021Article
- Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction.Frontiers in cell and developmental biology · 2021Article
- miR-140-3p aggregates osteoporosis by targeting PTEN and activating PTEN/PI3K/AKT signaling pathway.Human cell · 2020Article
- Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2020Review
- MicroRNA‑100‑5p inhibits osteoclastogenesis and bone resorption by regulating fibroblast growth factor 21.International journal of molecular medicine · 2019Article
- Biomaterial Enhanced Regeneration Design Research for Skin and Load Bearing Applications.Journal of functional biomaterials · 2019Review
- miR-193-3p ameliorates bone resorption in ovariectomized mice by blocking NFATc1 signaling.International journal of clinical and experimental pathology · 2019Article
- Mesenchymal Stem Cells and Transforming Growth Factor-β₃ (TGF-β₃) to Enhance the Regenerative Ability of an Albumin Scaffold in Full Thickness Wound Healing.Journal of functional biomaterials · 2018Article
- A Molecular View of Pathological Microcalcification in Breast Cancer.Journal of mammary gland biology and neoplasia · 2016Review
- Prospect of Stem Cells in Bone Tissue Engineering: A Review.Stem cells international · 2016Review
- Regeneration of rabbit calvarial defects using cells-implanted nano-hydroxyapatite coated silk scaffolds.Biomaterials research · 2015Article
- Differentiation of immortalized human precartilaginous stem cells into nucleus pulposus-like cells.International journal of clinical and experimental pathology · 2015Article
- Biocompatibility and in vivo osteogenic capability of novel bone tissue engineering scaffold A-W-MGC/CS.Journal of orthopaedic surgery and research · 2014Article
- Enhanced healing of rat calvarial defects with MSCs loaded on BMP-2 releasing chitosan/alginate/hydroxyapatite scaffolds.PloS one · 2014Article
- Interaction between immobilized polyelectrolyte complex nanoparticles and human mesenchymal stromal cells.International journal of nanomedicine · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intervertebral disc degeneration often requires bony spinal fusion for long-term relief. Current arthrodesis procedures use bone grafts from autogenous bone, allogenic backed bone, or synthetic materials. Autogenous bone grafts can result in donor site morbidity and pain at the donor site, while allogenic backed bone and synthetic materials have variable effectiveness. Given these limitations, researchers have focused on new treatments that will allow for safe and successful bone repair and regeneration. Mesenchymal stem cells have received attention for their ability to differentiate into osteoblasts, cells that synthesize new bone. With the recent advances in scaffold and biomaterial technology as well as stem cell manipulation and transplantation, stem cells and their scaffolds are uniquely positioned to bring about significant improvements in the treatment and outcomes of spinal fusion and other injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.