Evidence map›Paper›PMID 22500099›Full record

ReviewJournal of biomedicine & biotechnology2012

Human blood-vessel-derived stem cells for tissue repair and regeneration.

Chien-Wen Chen, Mirko Corselli, Bruno Péault, Johnny Huard

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Characterization of Burn Eschar Pericytes.Journal of clinical medicine · 2020
    Article
  7. Perivascular Mesenchymal Progenitors for Bone Regeneration.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019
    Review
  8. Review
  9. Skeletal Muscle Regenerative Potential of Human MuStem Cells following Transplantation into Injured Mice Muscle.Molecular therapy : the journal of the American Society of Gene Therapy · 2018
    Article
  10. CD34+ Stem Cell Treatment for Knee Osteoarthritis: A Treatment and Rehabilitation Algorithm.Journal of rehabilitation medicine. Clinical communications · 2018
    Review
  11. Article
  12. Vascular precursor cells in tissue injury repair.Translational research : the journal of laboratory and clinical medicine · 2017
    Review
  13. Review
  14. Review
  15. Muscle injuries and strategies for improving their repair.Journal of experimental orthopaedics · 2016
    Review
  16. Microvascular Fragment Transplantation Improves Rat Dorsal Skin Flap Survival.Plastic and reconstructive surgery. Global open · 2016
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Chien-Wen ChenDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA. chc88@pitt.edu
Mirko Corselli
Bruno Péault
Johnny Huard
Orthopaedic Hospital · USUniversity of Edinburgh · GBUniversity of Pittsburgh · USUniversity of Pittsburgh Medical Center · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Medical Research Council G1000816NIA NIH HHS P30 AG024827
6 · The paper itself

Abstract

Multipotent stem/progenitor cells with similar developmental potentials have been independently identified from diverse human tissue/organ cultures. The increasing recognition of the vascular/perivascular origin of mesenchymal precursors suggested blood vessels being a systemic source of adult stem/progenitor cells. Our group and other laboratories recently isolated multiple stem/progenitor cell subsets from blood vessels of adult human tissues. Each of the three structural layers of blood vessels: intima, media, and adventitia has been found to include at least one precursor population, that is, myogenic endothelial cells (MECs), pericytes, and adventitial cells (ACs), respectively. MECs and pericytes efficiently regenerate myofibers in injured and dystrophic skeletal muscles as well as improve cardiac function after myocardial infarction. The applications of ACs in vascular remodeling and angiogenesis/vasculogenesis have been examined. Our recent finding that MECs and pericytes can be purified from cryogenically banked human primary muscle cell culture further indicates their potential applications in personalized regenerative medicine.

Indexed as

Adult Stem CellsBlood VesselsHumansTissue EngineeringWound Healing

Identifiers

PMID22500099
PMCPMC3303622
OpenAlexW2055976359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.